mouse monoclonal IgG2a; Rho GDI Antibody (G-3) is an IgG2a κ mouse monoclonal Rho GDI antibody (also designated RhoGDI antibody) that detects the Rho GDI protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. Rho GDI Antibody (G-3) is available as both the non-conjugated anti-Rho GDI antibody form, as well as multiple conjugated forms of anti-Rho GDI antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The Ras superfamily of small GTP-binding proteins are critical mediators of diverse cell signaling pathways, including those leading to proliferation, cytoskeletal organization and secretion. The counter-conversion of the active GTP-bound form of these proteins to their inactive GDP-bound form is influenced by two types of regulatory proteins: those that alter the intrinsic GTPase activity of the GTP-binding proteins and those that alter the rate of GDP/GTP exchange. Guanine nucleotide-releasing factors (GRFs) increase the GDP dissociation rate, while GDP-dissociation inhibitors (GDIs) decrease the dissociation rate. The Rho GDI subfamily is composed of Rho GDIα, Ly-GDI (also known as Rho GDIβ and previously known as GDI/D4) and Rho GDIγ. The Rho GDI proteins interact with and have varying affinities for several Ras-like GTP binding proteins, including Rho A, Rho B, Rac and Cdc42. Ly-GDI is expressed only in hematopoietic cells, predominantly in B and T lymphocyte cell lines.