mouse monoclonal IgG1; Calbindin D28K Antibody (D-4) is an IgG1 κ mouse monoclonal Calbindin D28K antibody (also designated calbindin 1 antibody, CALB antibody, D-28K antibody, 28 kDa calcium-binding protein superfamily member antibody, Huntington disease related glutamate receptor calcium associated antibody, or vitamin D-dependent calcium-binding protein antibody) that detects the Calbindin D28K protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. Calbindin D28K Antibody (D-4) is available as both the non-conjugated anti-Calbindin D28K antibody form, as well as multiple conjugated forms of anti-Calbindin D28K antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The family of EF-hand type Ca2+-binding proteins includes Calbindin D28K, Calbindin D9K, S-100 α and β, Calgranulin A (also designated MRP8), Calgranulin B (also designated MRP14), Calgranulin C and the Parvalbumin family members, including Parvalbumin α and Parvalbumin β (also designated oncomodulin). Calbindin D28K, also known as calbindin, CALB1, D-28K or vitamin D-dependent calcium-binding protein, is a 261 amino acid protein with six EF-hand domains, four of which are active calcium-binding domains. Expressed in brain, ovary, uterus, testis, pancreas, liver, kidney and intestine, Calbindin D28K acts as a calcium-buffering agent and alters the activity of the plasma membrane ATPase. In neuronal cells, Calbindin D28K modulates calcium channel activity, calcium transients and intrinsic neuronal firing activity. Also, Calbindin D28K has been implicated to play a role in apoptosis and microtubule function.