mouse monoclonal IgG1; ARHGAP28 Antibody (G-3) is an IgG1 κ mouse monoclonal ARHGAP28 antibody (also designated ARHGAP28 antibody) that detects the ARHGAP28 protein of mouse, rat and human origin by WB, IP, IF and ELISA. ARHGAP28 Antibody (G-3) is available as both the non-conjugated anti-ARHGAP28 antibody form, as well as multiple conjugated forms of anti-ARHGAP28 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. ARHGAP28 (rho GTPase activating protein 28), also known as KIAA1314, is a 729 amino acid protein that contains one helical Rho-GAP domain. Expressed at moderate levels in ovary and kidney and at lower levels in skeletal muscle and spleen, ARHGAP28 functions as a negative regulator of Rho-type GTPases, specifically catalyzing the conversion of the target GTPase to an inactive, GDP-bound state. ARHGAP28, which exists as four alternatively spliced isoforms, is subject to DNA damaged-induced phosphorylation, possibly by ATM or ATR. The gene encoding ARHGAP28 localizes to human chromosome 18, which houses over 300 protein-coding genes and contains nearly 76 million bases. There are a variety of diseases associated with defects in chromosome 18-localized genes, some of which include Trisomy 18 (also known as Edwards syndrome), Niemann-Pick disease, hereditary hemorrhagic telangiectasia, erythropoietic protoporphyria and follicular lymphomas.