mouse monoclonal IgG1; BMAL1 Antibody (B-1) is an IgG1 κ mouse monoclonal BMAL1 antibody (also designated ARNTL antibody) that detects the BMAL1 protein of mouse, rat and human origin by WB, IP, IF and ELISA. BMAL1 Antibody (B-1) is available as both the non-conjugated anti-BMAL1 antibody form, as well as multiple conjugated forms of anti-BMAL1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. AhR, Arnt 1, Arnt 2 and BMAL1 are members of a family of transcription factors that contain a basic helix-loop-helix motif and a common "PAS" motif. The aromatic (aryl) hydrocarbon receptor, AhR, is a ligand dependent transcription factor that interacts with specific DNA sequences termed xenobiotic responsive elements (XREs) to activate several genes including CYP1A1, glutathione S-transferase Ya subunit and DT-diaphorase. The Ah receptor nuclear translocator proteins (Arnt 1 or Arnt 2) are required for ligand-dependent nuclear translocation of the Ah receptor and are also necessary for Ah receptor binding to the XRE element. BMAL1 (brain and muscle Arnt-like protein 1), also designated Arnt3, TIC, JAP3 or MOP3, has been shown to dimerize with Clock and bind to the promoter region of mPer1, suggesting that this protein plays a role in regulation of circadian oscillation in mammals.