mouse monoclonal IgG1; MASP-2 Antibody (B-10) is an IgG1 κ mouse monoclonal MASP-2 antibody (also designated MASP-2 antibody) that detects the MASP-2 protein of human origin by WB, IP, IF and ELISA. MASP-2 Antibody (B-10) is available as both the non-conjugated anti-MASP-2 antibody form, as well as multiple conjugated forms of anti-MASP-2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Mannose (or mannan)-binding lectin (MBL), also known as serum mannose-binding protein (MBP), initiates the lectin branch of the innate immune response by binding to the surface of potentially pathogenic microorganisms and initiating complement fixation through an N-terminal collagen-like domain. MBL is a key component in immune response in that it can directly trigger neutralization of invading microorganisms by an Ab-independent mechanism. Mutations of human MBL are associated with immunodeficiency resulting from a reduction in the ability of the mutant MBL to initiate complement fixation. In human, three types of MBL-associated serine proteases, MASP-1, MASP-2 and MASP-3, and a truncated form of MASP-2 (small MBL-associated protein; sMAP or MAp19) complex with MBL to activate the lectin pathway of the complement system. Activated MASPs subsequently cleave and activate downstream components of the complement pathway. MASP-3 is an alternatively spliced product from the MASP-1 gene and may function to inhibit MASP-2 by competing for MBL binding and inhibiting the activation of MBL-associated MASP-2.