mouse monoclonal IgG1; nm23-H1 Antibody (NM301) is an IgG1 κ mouse monoclonal nm23-H1 antibody (also designated NDKA antibody, NME/NM23 Nucleoside Diphosphate Kinase 1 antibody, NDPKA antibody, NM23 antibody, Non-Metastatic Cells 1 Protein (NM23A) Expressed In antibody, Tumor Metastatic Process-Associated Protein antibody, Metastasis Inhibition Factor Nm23 antibody, Nucleoside Diphosphate Kinase A antibody, Granzyme A-Activated DNase antibody, NDPK-A antibody, or NDK A antibody) that detects the nm23-H1 protein of mouse, rat and human origin by IP, IF and IHC(P). nm23-H1 Antibody (NM301) is available as both the non-conjugated anti-nm23-H1 antibody form, as well as multiple conjugated forms of anti-nm23-H1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The nm23 gene, a potential suppressor of metastasis, was originally identified by differential hybridization between two murine melanoma sub-lines, one with a high and the second with a low metastatic capacity. Highly metastatic sub-lines exhibit much lower levels of nm23 than less metastatic cells. Based on sequence analysis, nm23 appears highly related to nucleotide diphosphate kinases (NDP). In humans, NDP kinases A and B are identical to two isotypes of human nm23 homologs, namely nm23-H1 and H2, respectively. nm23-H2 is identical in sequence to PuF, a transcription factor that binds to nuclease-hypersensitive elements at positions 142 to 115 of the human C-Myc promotor.