mouse monoclonal IgG2a; Cytokeratin 15 Antibody (LHK15) is an IgG2a κ mouse monoclonal Cytokeratin 15 antibody (also designated KRT15 antibody, or Keratin 15 antibody) that detects the Cytokeratin 15 protein of mouse, rat and human origin by WB, IP, IF and IHC(P). Cytokeratin 15 Antibody (LHK15) is available as both the non-conjugated anti-Cytokeratin 15 antibody form, as well as multiple conjugated forms of anti-Cytokeratin 15 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Cytokeratin 15 (CK15, K15, K1CO, keratin15, type I cytoskeletal 15) is an intermediate filament (IF) type I protein that is responsible for the mechanical integrity of epithelial cells. Keratin family members are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains, and are clustered in a region on chromosome 17q21.2. Cytokeratin 15 is a specific marker of stem cells of the hair-follicle bulge and may be a useful marker for diagnosis between basal cell carcinoma and trichoepithelioma. Trichoblastoma are benign neoplasms of follicular differentiation frequently found in nevus sebaceus. Many morphologic features are shared with nodular basal cell carcinoma, sometimes rendering a diagnosis difficult. Trichoblastoma and BCC show variable expression of Cytokeratin 15 and Cytokeratin 19, and absence of hair keratins.