mouse monoclonal IgG2a; RPA194 Antibody (C-1) is an IgG2a κ mouse monoclonal RPA194 antibody (also designated polymerase (RNA) I polypeptide A, 194kDa antibody, A190 antibody, RPA1 antibody, RPO14 antibody, Acrofacial Dysostosis–Cincinnati type antibody, AFDCIN antibody, RPA190 antibody, or RPO1-4 antibody) that detects the RPA194 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. RPA194 Antibody (C-1) is available as both the non-conjugated anti-RPA194 antibody form, as well as multiple conjugated forms of anti-RPA194 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. RNA polymerases transcribe nuclear genes for ribosomal RNA, thus representing ribosomal biogenesis. RNA polymerase I (Pol I) is located in the nucleolus and transcribes class I genes, which code for large ribosomal RNA. Different subunits of the Pol I transcription machinery are targets of various physiological stimuli, which suggests that multiple signaling pathways are involved in carrying out Pol I transcription. RPA40 and RPA16 are subunits of Pol I that associate with each other at an early stage of RNA polymerase I assembly. RPA40 is essential for the function and integrity of the complex and is also an essential subunit of RNA polymerase III (Pol III). RPA40, RPA16 and RPA135 encode the three subunits of RNA polymerase I, respectively. RPA194 is the largest subunit of RNA Pol I and is not a component of Pol II and Pol III.