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Santa Cruz Biotechnology is a world leader in the development of products for the biomedical research market. Over the past 30+ years, the Company has focused on the ongoing development of research antibodies, siRNA and CRISPR Gene editing tools, biochemicals, labware and more recently has expanded into animal health care products. Santa Cruz Biotechnology has the highest commitment to quality and customer service.
Santa Cruz Biotechnology
GRB2 (1-68) | Santa Cruz Biotechnology
mouse monoclonal IgG2b; The superfamily of GTP binding proteins, of which Ras proteins are prototypes, has been implicated in a broad range of biological activities. A family of guanine nucleotide releasing factors (GRFs) activate Ras in mammalian cells and growth factor receptor-bound protein 2 (GRB2), an adaptor protein (also referred to as Sem 5) that appears to mediate the interaction of GRFs with activated receptor molecules. GRB2 forms a complex with activated EGFR (epidermal growth factor receptor) and the Ras-specific guanine nucleotide exchange factor SOS1, and, together, they regulate the growth factor-induced activation of Ras. GRB2 exhibits both structural and functional homology to the C. elegans protein sem-5. GRB2 is necessary during embryogenesis for the differentiation of endodermal cells and formation of the epiblast.
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