mouse monoclonal IgG2a; mSin3A Antibody (G-11) is an IgG2a κ mouse monoclonal mSin3A antibody (also designated SIN3A antibody) that detects the mSin3A protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. mSin3A Antibody (G-11) is available as both the non-conjugated anti-mSin3A antibody form, as well as multiple conjugated forms of anti-mSin3A antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. It is now well established that Myc regulation of cell proliferation and differentiation involves a family of related transcription factors. One such factor, Max, is an obligate heterodimeric partner for Myc and can also form heterodimers with at least four related proteins designated Mad 1, Mxi1 (alternatively designated Mad 2), Mad 3 and Mad 4. Like Mad 1 and Mxi1, association of Mad 3 and Mad 4 with Max results in transcriptional repression. Both Myc and the Mad proteins have short half-lives and their synthesis is tightly regulated, while Max expression is constitutive and relatively stable. Two related mammalian cDNAs have been identified and shown to encode Mad-binding proteins. Both possess sequence homology with the yeast transcription repressor Sin3 including four conserved paired amphipathic helix (PAH) domains. mSin3A and mSin3B specifically interact with the Mad proteins via their second paired amphipathic helix domain (PAH2). It has been suggested that Mad-Max heterodimers repress transcription by tethering mSin3 to DNA as corepressors.