mouse monoclonal IgG1; WASP Antibody (D-1) is an IgG1 κ mouse monoclonal WASP antibody (also designated WASP antibody or Wiskott-Aldrich Syndrome Protein antibody) that detects WASP of human origin by WB, IP, IF, IHC(P), FCM and ELISA. WASP Antibody (D-1) is available as the non-conjugated anti-WASP antibody form, as well as multiple conjugated forms of anti-WASP antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The Wiskott-Aldrich syndrome (WAS) is a disorder that results from a monogenic defect that has been mapped to the short arm of the X chromosome. WAS is characterized by thrombocytopenia, eczema, defects in cell-mediated and humoral immunity and a propensity for lymphoproliferative disease. The gene that is mutated in the syndrome encodes a proline-rich protein of unknown function designated WAS protein (WASP). A clue to WASP function came from the observation that T cells from affected males had an irregular cellular morphology and a disarrayed cytoskeleton suggesting the involvement of WASP in cytoskeletal organization. Close examination of the WASP sequence revealed a putative Cdc42/Rac interacting domain, homologous with those found in PAK65 and ACK. Subsequent investigation has shown WASP to be a true downstream effector of Cdc42.