mouse monoclonal IgG2b; p63α Antibody (C-12) is an IgG2b κ mouse monoclonal p63α antibody (also designated p63α antibody or TP63 antibody) that detects tA* p63α and ΔN p63α of human origin by WB, IP, IF, IHC(P) and ELISA. p63α Antibody (C-12) is available as the non-conjugated anti-p63α antibody form, as well as multiple conjugated forms of anti-p63α antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Transcription factor p63 is a widely expressed nuclear protein that exists as twelve isoforms and is a member of the p53 gene family. Alternate promoters encode two main variants, TAp63 and ΔNp63, which are further spliced into at least five isoforms, designated α, β, γ, δ and ε, due to alternative splicing events at the carboxy-terminus. TAp63 is transcribed from an upstream promoter containing a similar transactivation domain to p53, while ΔNp63 is transcribed from a promoter located on intron 3, that results in a unique transactivation domain and distinct biological functions. Considered to be oncogenic, ΔNp63 is required for cell growth and survival and can be dominant-negative over TAp63 and p53. TAp63 can transactivate some p53 target genes and is primarily responsible for tubulogenesis and cyst formation.