mouse monoclonal IgG1; CaMKIIα/β/γ/δ Antibody (G-1) is an IgG1 κ mouse monoclonal CaMKIIα/β/γ/δ antibody (also designated CAMK2A antibody or calcium/calmodulin dependent protein kinase II alpha/beta/gamma/delta antibody) that detects the CaMKIIα/β/γ/δ protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. CaMKIIα/β/γ/δ Antibody (G-1) is available as both the non-conjugated anti-CaMKIIα/β/γ/δ antibody form, as well as multiple conjugated forms of anti-CaMKIIα/β/γ/δ antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is a ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+ and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription. There are four CaMKII isozymes designated α, β, γ and δ, which may or may not be co-expressed in the same tissue type. CaMKIV is stimulated by Ca2+ and CaM but also requires phosphorylation by a CaMK for full activation. Stimulation of the T cell receptor CD3 signaling complex with an anti-CD3 monoclonal antibody leads to a 10-40 fold increase in CaMKIV activity. An additional kinase, CaMKK, functions to activate CaMKI through the specific phosphorylation of the regulatory Threonine residue at position 177.