mouse monoclonal IgG1; neuropilin Antibody (A-12) is an IgG1 κ mouse monoclonal neuropilin antibody (also designated NRP1 antibody, or neuropilin 1 antibody) that detects the neuropilin protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. neuropilin Antibody (A-12) is available as both the non-conjugated anti-neuropilin antibody form, as well as multiple conjugated forms of anti-neuropilin antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Neuropilin is a type I transmembrane receptor that has been implicated in aspects of axon growth and guidance and has been shown to act as a high affinity receptor for class III semaphorins and vascular endothelial growth factor (VEGF). A closely related protein, neuropilin-2, shares a common domain structure and signifcant homology with neuropilin and also acts as a receptor for the class III semaphorins and VEGF. Both neuropilins are involved in regulating many physiological pathways including axonal guidance and angiogenesis, however they exhibit differential expression in the adult vasculature. Neuropilin-2 is polysialylated and expressed on the surface of dendritic cells. It is also expressed by venous and lymphatic endothelium. Neuropilin is expressed predominantly by arterial endothelium.