mouse monoclonal IgM; MYH7 Antibody (A4.840) is an IgM κ mouse monoclonal MYH7 antibody (also designated MYHCB antibody, Myosin-7 antibody or Myosin heavy chain cardiac muscle beta antibody) that detects the MYH7 protein of mouse, rat, human, rabbit and avian origin by WB, IP, IF and IHC(P). MYH7 Antibody (A4.840) is available as both the non-conjugated anti-MYH7 antibody form, as well as multiple conjugated forms of anti-MYH7 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Myosin heavy chains are ubiquitous Actin-based motor proteins that convert the chemical energy derived from ATP hydrolysis into the mechanical energy that drives diverse motile processes in eukaryotic cells, including cytokinesis, vesicular transport and cellular locomotion. Muscle myosin is a heterohexamer consisting of two myosin heavy chains and two associated nonidentical pairs of myosin light chains. The seven myosin heavy chain isoforms that predominate in mammalian skeletal muscles include two developmental isoforms, MHC-embryonic (MYH3) and MHC-perinatal (MYH8); three adult skeletal muscle isoforms, MHC IIa (MYH2), MHC IIb (MYH4) and MHC IIx/d (MYH1); and MHC-β/slow (MYH7 or MHC-β), which is also expressed in cardiac muscle. Research indicates that mutations of the MYH7 gene causes hypertrophic cardiomyopathy.