mouse monoclonal IgG2b; KIR2DL4 Antibody (2H6) is an IgG2b mouse monoclonal KIR2DL4 antibody (also designated KIR2DL4 antibody) that detects the KIR2DL4 protein of human origin by WB and IP. KIR2DL4 Antibody (2H6) is available as the non-conjugated anti-KIR2DL4 antibody. NKAT (NK-associated transcripts) gene products, known as killer immuno-globulin-like receptors or KIRs, downregulate the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells. This family of receptors is characterized by an extracellular region with two to three immunoglobulin-superfamily domains and a cytoplasmic domain with an antigen receptor activation motif (ARAM). KIRs and other inhibitory receptors also possess a common cytoplasmic sequence (I/VxYxxL/V) known as an ITIM (immunoreceptor tyrosine-based inhibitory motif). The human inhibitory human killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4), also referred to as 2DL4 or CD158d, triggers potent IFN-γ responses but weak cytotoxicity in resting NK cells because of the low stoichiometric association with γ.