mouse monoclonal IgM; FucT-IV Antibody (MY-1) is an IgM mouse monoclonal FucT-IV antibody that detects FucT-IV of human origin by IF and IHC(P). FucT-IV Antibody (MY-1) is available as the non-conjugated anti-FucT-IV antibody form. Fucosyltransferases (FucTs) catalyze the covalent association of fucose to different positional linkages on sugar acceptor molecules. The carbohydrate moieties that are generated are covalently attached to cell surfaces and are necessary to ensure a surface contour that satisfies a variety of physiological roles. FucT-IV (a 1,3-fucosyltransferase IV), also known as FUT4, FCT3A or ELFT, is a 405 amino acid single-pass type II membrane protein that localizes to golgi stacks. During embryogenesis, FucT-IV is highly expressed in skin, liver, kidney, muscle and small intestine where it functions to catalyze the glycosidic attachment of a-fucose to various molecules, such as N-acetyllactosamines. Via its catalytic activity, FucT-IV participates in the synthesis of carbohydrate molecules like the cell-adhesion antigen CD15 (also known as Lewis X), thereby playing a roll in cell cycle events such as apoptosis and cell-cell binding. Overexpression of FucT-IV is implicated in epithelial cancers, suggesting a possible role for FucT-IV in carcinogenesis.