mouse monoclonal IgG2b; Cdk5 Antibody (J-3) is an IgG2b κ mouse monoclonal Cdk5 antibody (also designated cyclin dependent kinase 5 antibody or PSSALRE antibody) that detects the Cdk5 protein of mouse, rat and human origin by WB, IP, IF and ELISA. Cdk5 Antibody (J-3) is available as both the non-conjugated anti-Cdk5 antibody form, as well as multiple conjugated forms of anti-Cdk5 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Cell cycle progression is controlled in part by a family of cyclin proteins and cyclin dependent kinases (Cdks). Cdk proteins work in concert with the cyclins to phosphorylate key substrates involved in each phase of cell cycle progression. Another family of proteins, Cdk inhibitors, also plays a role in regulating cell cycle by binding to cyclin-Cdk complexes and modulating their activity. Several Cdk proteins have been identified, including Cdk2-Cdk8, PCTAIRE-1-3, PITALRE and PITSLRE. Cdk5 is thought to be involved in the G1-S transition of the cell cycle and is highly expressed in mature neurons. Activity of Cdk5 increases significantly during neuronal differentiation. Cdk5 has been postulated to be a neurofilament or tau protein kinase, based on its ability to phosphorylate these proteins in vitro.