mouse monoclonal IgG; Flk-1/KDR/VEGFR2 Antibody (A-3) is an IgG1 κ mouse monoclonal VEGFR2 antibody that detects VEGFR2 of mouse, rat and human origin by WB, IP, IF and IHC(P). Flk-1/KDR/VEGFR2 Antibody (A-3) is available as the non-conjugated anti-VEGFR2 antibody form, as well as multiple conjugated forms of anti-VEGFR2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Three cell membrane receptor tyrosine kinases, Flt (also designated VEGF-R1) (1-3), Flk-1 (also designated VEGF-R2) (4-6) and Flt-4, putatively involved in the growth of endothelial cells, are characterized by the presence of seven immunoglobulin-like sequences in their extracellular domain. These receptors exhibit high degrees of sequence relatedness to each other as well as lesser degrees of relatedness to the class III receptors including CSF-1/Fms, PDGR, SLFR/Kit and Flt-3/Flk-2. Two members of this receptor class, Flt-1 and Flk-1, have been shown to represent high affinity receptors for vascular endothelial growth factors (VEGFs) (3,5). On the basis of structural similarity to Flt and Flk-1, it has been speculated that Flt-4 might represent a third receptor for either VEGF or a VEGF-related ligand.