mouse monoclonal IgG1; Dok-1 Antibody (A-3) is an IgG1 κ mouse monoclonal Dok-1 antibody (also designated DOK1 antibody) that detects the Dok-1 protein of mouse, rat and human origin by WB, IP, IF and IHC(P). Dok-1 Antibody (A-3) is available as both the non-conjugated anti-Dok-1 antibody form, as well as multiple conjugated forms of anti-Dok-1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Dok-1 associates with the Ras GTPase-activating protein (Ras GAP) upon tyrosine phosphorylation. Evidence suggests that Dok-1 (also designated p62dok) is a substrate of the constitutive tyrosine kinase activity of p210 Bcr-Abl, a fusion protein caused by the t(9;22) translocation and associated with chronic myelogenous leukemia. Dok-1, as well as the tyrosine kinase substrates IRS-1 and Cas, are members of a class of "docking" proteins which contain multiple tyrosine residues and putative SH2 binding sites. Dok-1 is suspected to be the substrate phosphorylated in response to stimulation by a number of growth factors, including PDGF, VEGF, insulin and IGF. Dok-2 (also designated p56dok) has also been identified as a potential mediator of the effects of p210 Bcr-Abl.