mouse monoclonal IgG1; c-Rel Antibody (B-6) is an IgG1 λ mouse monoclonal c-Rel antibody (also designated REL antibody) that detects the c-Rel protein of mouse, rat and human origin by WB, IP, IF and IHC(P). c-Rel Antibody (B-6) is available as both the non-conjugated anti-c-Rel antibody form, as well as multiple conjugated forms of anti-c-Rel antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. c-Rel is the cellular cognate of v-Rel, the avian reticuloendotheliosis virus strain T transforming gene. v-Rel encodes a phosphoprotein that is located in the cytoplasm of transformed spleen cells and in the nucleus of non-transformed fibroblasts, in contrast to the c-Rel protein, which is cytoplasmic. c-Rel has been shown to represent a constituent of the κB site binding transcription factor NFκB, which plays a crucial role in the expression of immunoglobulin κ light chain gene. In contrast to c-Rel, v-Rel is truncated in its C-terminal transactivation domain and does not appear to function as a transcriptional transactivator. It has thus been postulated that v-Rel may interfere with the normal transcription of NFκB regulated genes and thus cause transformation by a mechanism analogous to v-ErbA, which binds to the thyroid hormone-responsive region in certain erythroid genes needed for differentiation, but cannot be activated by thyroid hormone.