mouse monoclonal IgG1; MYH11 Antibody (G-4) is an IgG1 λ mouse monoclonal MYH11 antibody (also designated SMMHC antibody, Myosin-11 antibody, Myosin heavy chain 11 antibody or Myosin heavy chain, smooth muscle isoform antibody) that detects the MYH11 protein of mouse, rat and human origin by WB, IP, IF, FCM and ELISA. MYH11 Antibody (G-4) is available as both the non-conjugated anti-MYH11 antibody form, as well as multiple conjugated forms of anti-MYH11 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Myosin is a highly conserved, ubiquitously expressed protein that interacts with Actin to generate the force for cellular movements. Conventional Myosins are hexameric proteins consisting of two heavy chain subunits, a pair of non-phosphorylatable light chain subunits and a pair of phosphorylatable light chain subunits. Three general classes of Myosin have been cloned: smooth muscle Myosins (such as MYH11), striated muscle Myosins and non-muscle Myosins. Contractile activity in smooth muscle is regulated by the calcium/calmodulin-dependent phosphorylation of Myosin light chain (MLC) by Myosin light chain kinase. Myosin heavy chains, encoded by the MYH gene family, contain Actin-activated ATPase activity which generates the motor function of Myosin. Myosin heavy chains were initially isolated from a human fetal skeletal muscle and are the major determinant in the speed of contraction of skeletal muscle. Various isoforms of myosin heavy chains are differentially expressed depending on the functional activity of the muscle.