mouse monoclonal IgG2a; GSK-3α/β Antibody (0011-A) is an IgG2a κ mouse monoclonal GSK-3 alpha / beta antibody (also designated GSK3B antibody, glycogen synthase kinase 3 antibody or GSK3 antibody) that detects the GSK-3 alpha / beta protein of mouse, rat, human, canine and Xenopus origin by WB, IP, IF, IHC(P) and FCM. GSK-3α/β Antibody (0011-A) is available as both the non-conjugated anti-GSK-3 alpha / beta antibody form, as well as multiple conjugated forms of anti-GSK-3 alpha / beta antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Glycogen synthase kinase 3, or GSK-3, is a serine/threonine, proline-directed kinase involved in a diverse array of signaling pathways, including glycogen synthesis and cellular adhesion, and has been implicated in Alzheimer's disease. Two forms of GSK-3, designated GSK-3α and GSK-3β, have been identified and differ in their subcellular localization. Tau, a microtubule-binding protein which serves to stabilize microtubules in growing axons, is found to be hyper-phosphorylated in paired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimer's disease. Hyperphosphorylation of Tau is thought to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK-3. This presents the possibility that miscues in GSK-3 signaling contribute to the onset of Alzheimer's disease.