mouse monoclonal IgG1; CD6 Antibody (SPV-L14) is an IgG1 κ mouse monoclonal CD6 antibody (also designated CD6 antibody) that detects the CD6 protein of mouse, rat and human origin by WB, IP, IF and FCM. CD6 Antibody (SPV-L14) is available as both the non-conjugated anti-CD6 antibody form, as well as multiple conjugated forms of anti-CD6 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. CD6 is a type I transmembrane glycoprotein that is present on mature thymocytes, peripheral T cells and a subset of B cells. The CD6 glycoprotein is tyrosine phosphorylated during TCR-mediated T-cell activation and the size difference between the CD6 forms is due in part to differences in phosphorylation state. CD6 protein contains a 24-amino acid signal sequence, three extracellular "scavenger receptor cysteine-rich" (SRCR) domains, a membrane-spanning domain, and a 44-amino acid cytoplasmic domain. CD6 shows significant homology to CD5. CD6, which is also found in brain and B cell chronic lymphocytic leukemias, plays an important role in interactions of thymocytes with thymic epithelial cells. CD6 molecules can physically associate with the TCR/CD3 complex.