mouse monoclonal IgG2a; TAF II p130 Antibody (4A6) is an IgG2a κ mouse monoclonal TAF II p130 antibody (also designated TAF II p130 antibody) that detects the TAF II p130 protein of human origin by WB, IP, IF and IHC(P). TAF II p130 Antibody (4A6) is available as both the non-conjugated anti-TAF II p130 antibody form, as well as multiple conjugated forms of anti-TAF II p130 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. TFIID is a general transcription factor which initiates preinitiation complex assembly through direct interaction with the TATA promoter element. It is a multisubunit complex consisting of a small TATA-binding polypeptide and other TBP-associated factors (TAFs). Although native TFIID can mediate both activator-independent (basal) and activator-dependent transcription in reconstituted systems, TBP can mediate only basal transcription. The largest subunit (TAF) of TFIID is a protein designated TAF II p250. Of interest, TAF II p250 has been cloned and shown to be identical to CCG1, a nuclear DNA-binding protein known to be important for cell cycle progression. This part of TAF II p250 may serve a specific function in activation of a subset of genes important for cell cycle progression. Human TAFII p130 is a coactivator for NFAT transcriptional activators that regulate the expression of cytokines.