mouse monoclonal IgG1; PPARβ Antibody (F-10) is an IgG1 κ mouse monoclonal PPAR beta antibody (also designated PPARD antibody, peroxisome proliferator activated receptor delta antibody, peroxisome proliferator-activated receptor (PPAR) family member delta antibody, PPAR beta antibody, or PPAR-δ antibody) that detects the PPAR beta protein of mouse, rat and human origin by WB, IP, IF and ELISA. PPARβ Antibody (F-10) is available as both the non-conjugated anti-PPAR beta antibody form, as well as multiple conjugated forms of anti-PPAR beta antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that can be activated by a variety of compounds including fibratus, thiazolidinediones, prostaglandins and fatty acids. Three PPAR subtypes, designated PPARα, PPARβ (also designated PPARδ) and PPARγ, have been described. PPARs promote transcription by forming heterodimers with members of the retinoid X receptor (RXR) family of steroid receptors and binding to specific DNA motifs termed PPAR-response elements (PPREs). PPARα is abundant in primary hepatocytes, where it regulates the expression of proteins involved in fatty acid metabolism. PPARβ is the most widely distributed subtype and is often expressed at high levels. PPARγ is predominantly seen in adipose tissue, where it plays a critical role in regulating adipocyte differentiation. Interestingly, both the orphan nuclear hormone receptor LXRα and thyroid receptor (TR) have been shown to act as antagonists of PPARα/RXRα binding to PPREs.