mouse monoclonal IgG2a; HDAC7 Antibody (A-7) is an IgG2a κ mouse monoclonal HDAC7 antibody (also designated Histone Deacetylase 7 antibody) that detects the HDAC7 protein of human origin by WB, IP, IF and ELISA. HDAC7 Antibody (A-7) is available as both the non-conjugated anti-HDAC7 antibody form, as well as multiple conjugated forms of anti-HDAC7 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1, and the TFIID subunit TAF II p250. Mammalian HDAC7 is a histone deacetylase that interacts with the adaptor mSin3A. The interaction of HDAC7 with mSin3A suggests the association of multiple repression complexes of transcription factors.