mouse monoclonal IgG1; p38 alpha/beta MAPK Antibody (A-12) is an IgG1 κ mouse monoclonal p38 alpha/beta MAPK antibody (also designated p38α/β antibody, MAPK14/MAPK11 antibody, SAPK2A/SAPK2B antibody or p38a/p38b antibody) that detects the p38 alpha/beta MAPK protein of mouse, rat and human origin by WB, IP, IF, IHC(P), FCM and ELISA. p38 alpha/beta MAPK Antibody (A-12) is available as both the non-conjugated anti-p38 alpha/beta MAPK antibody form, as well as multiple conjugated forms of anti-p38 alpha/beta MAPK antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. MAP (mitogen-activated protein) kinases play a significant role in many biological processes, including cell adhesion and spreading, cell differentiation and apoptosis. p38 alpha MAPK14, p38 beta MAPK11 and p38 gamma MAPK12 each contain one protein kinase domain and belong to the MAP kinase family. Expressed in different areas throughout the body with common expression patterns in heart, p38 proteins use magnesium as a cofactor to catalyze the ATP-dependent phosphorylation of target proteins. Via their catalytic activity, p38 alpha MAPK14, p38 beta MAPK11 and p38 gamma MAPK12 are involved in a variety of events throughout the cell, including signal transduction pathways, cytokine production and cell proliferation and differentiation. The p38 proteins are subject to phosphoryation on Thr and Tyr residues, an event which is thought to activate the phosphorylated protein.