mouse monoclonal IgG2a; BLNK Antibody (2B11) is an IgG2a κ mouse monoclonal BLNK antibody (also designated B-cell adapter containing SH2 domain (BASH) antibody, Src homology [SH2] domain-containing leukocyte protein of 65 kD (SLP-65) antibody, SLP65 antibody, B-cell activation (BCA) protein antibody, B cell / macrophage spatial temporal signaling regulator antibody, or leucine zipper motif, proline-rich region, C-terminal SH2 domain containing protein antibody) that detects the BLNK protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. BLNK Antibody (2B11) is available as both the non-conjugated anti-BLNK antibody form, as well as multiple conjugated forms of anti-BLNK antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Cross-linking of the B cell receptor (BCR) activates a variety of signaling pathways involved in processes such as cell proliferation and apoptosis. Intracellular protein tyrosine kinases such as Syk and Lyn have been implicated in this BCR signal transduction and are thought to play an important role in B cell development. BLNK (for B cell linker protein) is a central linker protein in B cells which has been shown to associate with the effector proteins GRB2, Vav, Nck and PLC γ following activation of the B cell receptor. The two forms of BLNK, pp68 and pp70, arise from alternate splicing of the human BLNK gene transcript. BLNK is phosphorylated by the Syk tyrosine kinase, which in turn permits activation of downstream effector proteins including GRB2 and PLC γ.