mouse monoclonal IgG1; Ubiquitin Antibody (P4D1) is an IgG1 κ mouse monoclonal Ubiquitin antibody (also designated Ub antibody) that detects the Ubiquitin protein of mouse, rat, human and Drosophila melanogaster origin by WB, IP, IF, IHC(P), FCM and ELISA. Ubiquitin Antibody (P4D1) is available as both the non-conjugated anti-Ubiquitin antibody form, as well as multiple conjugated forms of anti-Ubiquitin antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Ubiquitin (Ub) is among the most phylogenetically conserved proteins known. The primary function of Ubiquitin is to clear abnormal, foreign and improperly folded proteins by targeting them for degradation by the 26S Proteosome. This small, 76 amino acid protein can be covalently attached to cellular proteins via an isopeptide linkage between the carboxy terminal group of Ubiquitin and lysine amino groups on the acceptor protein. For proteolysis to occur, Ubiquitin oligomers must be assembled. Ubiquitin chains on proteolytic substrates are commonly found to have an isopeptide bridge between Lys 48 of one Ubiquitin molecule and the carboxy-terminus of a neighboring Ubiquitin molecule. Ubiquitin also plays a role in regulating signal transduction cascades through the elimination inhibitory proteins, such as IκB-α and p27.