mouse monoclonal IgG1; Dvl-3/Dishevelled 3/DVL3 Antibody (4D3) is an IgG1 κ mouse monoclonal Dvl-3 antibody that detects Dvl-3 of mouse, rat and human origin by WB and IP. Dvl-3/Dishevelled 3/DVL3 Antibody (4D3) is available as the non-conjugated anti-Dvl-3 antibody form, as well as multiple conjugated forms of anti-Dvl-3 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Mammalian homologs of the Drosophila dishevelled (Dsh) gene have been identified, including Dvl-1, Dvl-2 and Dvl-3. The mammalian dishevelled proteins contain three homologous domains, two of which are unrelated to any other known protein. The third region is homologous to the discs-large homology domain of Drosophila discs-large-1, a tumor suppressor protein. Like their Drosophila counterpart, the dishevelled proteins are thought to be in-volved in embryogenesis. Overexpression of Dvl-1 has been shown to inhibit the phosphorylation of tau by GSK-3b. This finding may prove to be important in Alzheimer's studies, which have shown that tau is hyperphosphorylated. In Drosophila, Dsh is a component of the frizzled signaling pathway. Both mammalian dishevelled and frizzled proteins are components of the Wnt signalling pathway.