mouse monoclonal IgG2a; Daxx Antibody (H-7) is an IgG2a κ mouse monoclonal Daxx antibody (also designated death domain associated protein antibody, EAP1 antibody, BING2 antibody, SMIM40 antibody, or histone H3.3 chaperone antibody) that detects the Daxx protein of mouse, rat and human origin by WB, IP, IF and ELISA. Daxx Antibody (H-7) is available as both the non-conjugated anti-Daxx antibody form, as well as multiple conjugated forms of anti-Daxx antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Activation of the cell surface receptor FAS by FAS ligand leads to the initiation of apoptosis, a process necessary for the regulation of the immune system and tissue homeostasis. FAS-mediated apoptosis appears to involve a number of divergent and overlapping pathways. Daxx appears to be a central component of a FAS-mediated apoptotic pathway involving the activation of Jun N-terminal kinase (JNK). Although Daxx itself does not contain a death domain, it specifically binds to the death domain of FAS. Overexpression of Daxx activates the JNK pathway and enhances FAS-mediated apoptosis. The Daxx apoptotic pathway acts cooperatively with but is distinct from the FAS-mediated pathway that involves interactions between the death domain-containing protein FADD and the cysteine protease FLICE. Unlike the FAS-FADD-FLICE pathway, the Daxx pathway is sensitive to the apoptotic inhibitor protein Bcl-2.