mouse monoclonal IgG2b; c-Fos Antibody (D-1) is an IgG2b κ mouse monoclonal c-Fos antibody that detects c-Fos of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. c-Fos Antibody (D-1) is available as both conjugated and non-conjugated anti-c-Fos antibody forms. The c-Fos oncogene was initially detected in two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c-Fos, encodes a nuclear phospho-protein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers which bind to specific DNA response elements, c-Fos proteins are only active as heterodimers with members of the Jun gene family. Functional homologs of c-Fos include the Fra-1, Fra-2 and Fos B genes. In addition, selected ATF/CREB family members can form leucine zipper dimers with Fos and Jun. Different dimers exhibit differential specificity and affinity for AP-1 and CRE sites.