mouse monoclonal IgG1; DR4 Antibody (B-9) is an IgG1 κ mouse monoclonal DR4 antibody (also designated TNFRSF10A antibody, APO2 antibody, or TRAILR1 antibody) that detects the DR4 protein of human origin by WB, IP, IF and ELISA. DR4 Antibody (B-9) is available as both the non-conjugated anti-DR4 antibody form, as well as multiple conjugated forms of anti-DR4 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated by two distinct cell surface receptors, designated TNF-R1 and TNF-R2, which are expressed on most cell types. TNF function is primarily mediated through TNF-R1 signaling. Both receptors belong to the growing TNF receptor superfamily which includes FAS antigen and CD40. TNF-R1 contains a cytoplasmic motif, termed the "death domain," that has been found to be necessary for the transduction of the apoptotic signal. The death domain is also found in several other receptors, including FAS, DR2 (or TRUNDD), DR3 (Death Receptor 3), DR4 and DR5. TRUNDD, DR4 and DR5 are receptors for the apoptosis-inducing cytokine TRAIL. A non-death domain-containing receptor, designated decoy receptor (DcR1 or TRID), also specifically associates with TRAIL and may play a role in cellular resistance to apoptotic stimuli.