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Santa Cruz Biotechnology

p70 S6 kinase α (H-9) Alexa Fluor® 790 | Santa Cruz Biotechnology

mouse monoclonal IgG1; p70 S6 kinase α Antibody (H-9) is an IgG1 κ mouse monoclonal p70 S6 kinase alpha antibody (also designated p70S6K antibody, PS6K antibody or RPS6KB1 ribosomal protein S6 kinase B1 antibody) that detects the p70 S6 kinase alpha protein of mouse, rat and human origin by WB, IP, IF, IHC(P), FCM and ELISA. p70 S6 kinase α Antibody (H-9) is available as both the non-conjugated anti-p70 S6 kinase alpha antibody form, as well as multiple conjugated forms of anti-p70 S6 kinase alpha antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. In studies to elucidate key regulatory pathways in signal transduction, several protein serine/threonine (Ser/Thr) kinases have been identified, including two distinct families of 40S ribosomal protein S6 Ser/Thr kinases present in somatic animal cells, designated p70 S6 kinase and p90 Rsk kinase. p90 Rsk kinase is maximally activated within minutes of addition of growth factors or phorbol ester to cultured cells followed by activation of p70 S6 kinase. Both enzymes are regulated by serine/threonine phosphorylation, suggesting that specific kinases may exist upstream in the signaling pathway that regulate these kinases. In fact, evidence suggests that one such family of activating enzymes includes the members of the ERK MAP kinase family. The ERK MAP kinases are, in turn, regulated by phosphorylation at threonine and tyrosine residues by a protein kinase designated MEK.

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