mouse monoclonal IgG1; Fibronectin Antibody (EP5) is an IgG1 κ mouse monoclonal Fibronectin antibody (also designated FN1 antibody) that detects the Fibronectin protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. Fibronectin Antibody (EP5) is available as both the non-conjugated anti-Fibronectin antibody form, as well as multiple conjugated forms of anti-Fibronectin antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Fibronectin is an extracellular matrix glycoprotein present on most cell surfaces, in extracellular fluids and in plasma. A high molecular weight heterodimeric protein, it was originally discovered as a protein missing from the surfaces of virus-transformed cells, and it has been shown to be involved in various functions including cell adhesion, cell motility and wound healing. Alternative splicing and glycosylation give rise to several different forms of Fibronectin, some of which exhibit restricted tissue distribution or association with malignancies. It has been shown that Myofibroblast phenotype formation correlates with the occurrence of glycosylated Fibronectin and Fibronectin splice variants in Dupuytren's disease.