mouse monoclonal IgG1; E-cadherin Antibody (G-10) is an IgG1 κ mouse monoclonal E-cadherin antibody (also designated CD324 antibody, ECAD antibody or CDH1 antibody) that detects the E-cadherin protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. E-cadherin Antibody (G-10) is available as both the non-conjugated anti-E-cadherin antibody form, as well as multiple conjugated forms of anti-E-cadherin antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. Members of this family of adhesion proteins include rat cadherin K (and its human homolog, cadherin-6), R-cadherin, B-cadherin, E/P cadherin and cadherin-5. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The most distal of these cadherins is thought to be responsible for binding specificity, transmembrane domains and carboxy terminal intracellular domains. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as β-catenin, to regulate cadherin function.