Research models are used in medical research to mimic aspects of a disease or illness that occurs in humans. Research models can include animals (in vivo models), cell lines (in vitro models), or computer-driven demonstrations (in silico models). Research models allow doctors and scientists to uncover important information that can be applied to clinical practice.
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The printing press, the automobile & the Internet are just a few technological achievements that have advanced our world. All were driven by human ingenuity: our innate creativity that in...
Date: February 7, 2019Time: 8:00am PST, 11:00am EST Modern microscopes are becoming increasingly complex instruments enabling registration of image sets far beyon...
Development of novel types of therapeutics require adaptation of traditional bioprocessing applications to include the use of primary cells, such as stem cells, fibroblasts, astrocytes and ne...
As the pace of biotherapeutic approvals increases, so does the pressure on makers of new biologics to complete their development processes faster and more efficiently. The success of the drug...
DATE: December 18, 2018TIME: 10:00am PST, 1:00pm EST Precision medicine anticipates the clinical application of whole-genome sequencing (WGS), as evidenced by the...
DATE: December 13 15,2018TIME: 09:00am PST, 12:00pm EST Breast cancers are classified into three main subtypes according to their receptor status: estrogen receptor-positive...
DATE: December 11, 2018TIME: 06:00 PSTIt’s understood and accepted that animal disease models generally offer great value for pre-clinical research and efficient drug screeni...
DATE: December 6, 2018TIME: 9:00am PST, 12:00pm EST Induced pluripotent stem cells (iPSC) intended for translational applications need to be of...
DATE: December 6, 2018TIME: 11:00am EST, 5:00pm CET Introduction Micro-computed tomography (micro-CT) offers significant advantages o...
DATE: December 05, 2018TIME: 08:00 PSTWhat is desperately needed are methods to detect cells that cause metastasis–known as cancer stem cells (CSC), a subpopulation of...
DATE: December 6, 2018TIME: 10:00am CET, 5:00pm CST Intro Micro-computed tomography (micro-CT) offers significant advantage...
DATE: December 5, 2018TIME: 9:00AM PDTThe mouse is a critical, increasingly used model system in biomedical research and preclinical drug discovery. While technological advances en...
DATE: December 05, 2018TIME: 07:00 PSTWhat is desperately needed are methods to detect cells that cause metastasis–known as cancer stem cells (CSC), a subpopulation of...
DATE: December 4, 2018TIME: 4:00pm CET PSCs represent an important tool in a wide range of applications, including basic research, disease...
DATE: December 4, 2018TIME: 8:00am CET PSCs represent an important tool in a wide range of applications, including basic research, disease...
DATE: November 29, 2018TIME: 9:00AM PDTAn overview of primary immune deficiency disorders (PID) and laboratory testing for PIDPrimary immune deficiencies (PIDs), oth...
Generation of robust iPSC-derived neural stem cell cultures and neurons with shorter maturation times provide opportunities for quick and reliable generation of neuronal in vitro models. This...
The complexity of the human brain, with thousands of neuronal types, permits the development of sophisticated behavioral repertoires, such as language, tool use, self-awareness, symbolic thou...
Clinical testing with next generation sequencing requires a complex bioinformatics pipeline to process raw DNA sequence into interpretable variants for medical reporting. With sequencin...
CRISPR ribonucleoproteins (RNPs) can generate programmable gene edits, however imprecise editing and efficient delivery to human stem cells are key challenges. Here we describe novel biochemi...
The use of human pluripotent stem cells (hPSCs) for in vitro disease-modeling is limited by the lack of robust and efficient protocols for the differentiation of relevant adult cell types. Pr...
Neuronal migration defects, including pachygyria, are among the most severe developmental brain defects in humans. Using human genetics approaches, we recently identified bi-allelic truncatin...
With significant decrease in the cost of sequencing in numerous commercial as well as cancer center–driven initiatives, genomic profiling is increasingly becoming routine across multipl...