Biology: the study of living organisms, divided into many specialized fields that cover their morphology, physiology, anatomy, behavior, origin, and distribution. This includes plants, animals, and other qualities of organisms or class of organisms.
The Human Microbiome Project was conceived almost 15 years ago, as an extension of the Human Genome Project, to explore the diversity of human-associated microorganisms at multiple body site...
Influenza viruses represent a significant burden to human health. In order to limit respiratory viral disease, new approaches that can prevent viral infection and spread are needed. We have...
Self-amplifying RNA replicons are promising candidates for next generation vaccines against human coronaviruses with pandemic potential. Self-amplification of RNAs in host cells generates mo...
The ongoing COVID-19 pandemic has increased awareness about sex-specific differences in immunity and outcomes following respiratory virus infections. Strong evidence of a male bias in COVID-...
Flaviviruses are pathogens of global public health concern. They include dengue virus (DENV), West Nile virus (WNV), and zika virus (ZIKV). There are no approved US Food and Drug Administrat...
Date: July 07, 2021 Time: 8:00am (PDT), 11:00am (EDT) The DNA damage response is extremely crucial in maintaining genomic integrity. Failure to repair damaged DNA can result in the propagati...
Date: August 26, 2021 Time: 7:00am (PDT), 10:00am (EDT) Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease with rising incidence and a remarkable resistance to current therapies. In t...
In this preliminary experiment, we used spatial transcriptomics to assess the gene expression profiles of microglia or astrocytes in relation to their distance from plaques. We compared 18-m...
Technological advances such as single-cell RNA sequencing accelerated our understanding of cellular diversity in tissues. However, the ability to elucidate this cellular heterogeneity while...
In 1910, Harrison published the first report of frog embryonic sympathetic ganglia grown in hanging drops of lymph for a few days, where single neurons extended nerve fibers with complex gro...
The increasing burden of neurological disorders as our population ages, together with the high personal and societal costs of mental and substance use disorders, underscores the need for new...
The misfolding of intrinsically disordered proteins (IDPs) such as tau and α-synuclein (αSyn) has been associated with the on-set and progression of Alzheimer’s (AD) and Pa...
Adolescence is a critical period for the developing brain, and binge drinking during this neuromaturation can result in enduring abnormal brain function and behavior. Repeated adolescent bin...
Learning Objectives: 1. Delineate the goals of studies of brain, computation and behavior and how they can be integrated. 2. Describe how neuromodulators such as oxytocin transform circuits...
Learning Objections: 1. To learn a new approach to understanding brain function by creating networks to perform tasks using machine learning. 2. To learn how how to probe these networks to d...
Cortical circuits often receive multiple inputs from upstream populations with non-overlapping stimulus tuning. Both the feedforward and recurrent architectures of the receiving cortical lay...
Multiscale modeling has arisen as a focus of computational systems biology, with the realization that genome, proteome, connectome, etceteromes, will only become comprehensible once placed i...
One role of theory is in guiding future experiments: What should we aim to measure? Which experimental results should we be surprised about? I will argue here that simple random networks mod...
Alzheimer’s and Parkinson’s diseases (AD, PD) are the two most common neurodegenerative disorders. Despite their debilitating effects and increasing prevalence in society, no cur...
DATE: August 19, 2020 TIME: 8:00am PT, 11:00pm ET Type 2 diabetes mellitus (T2D) is associated with an increased risk of osteoporotic fractures. Several factors have been identified as being...
Date: August 18, 2021 Time: 8:00am (PDT), 11:00am (EDT) Discover the tools to phenotype your NK cells and to perform functional analyses such as cellular cytotoxicity assays. From NK cell is...
Date: July 29, 2021 Time: 10:00am (PDT), 1:00pm (EDT) Experts are predicting an increase in influenza cases and a constant presence of SARS-CoV-2 in the shortly approaching influenza season....
Date: July 28, 2021 Time: 8:00am PDT Breast cancer is the most common form of cancer in women. It is estimated that 1 out of 8 women in the US will develop invasive breast cancer during her...
The Human Microbiome Project was conceived almost 15 years ago, as an extension of the Human Genome Project, to explore the diversity of human-associated microorganisms at multiple body site...
Influenza viruses represent a significant burden to human health. In order to limit respiratory viral disease, new approaches that can prevent viral infection and spread are needed. We have...
Self-amplifying RNA replicons are promising candidates for next generation vaccines against human coronaviruses with pandemic potential. Self-amplification of RNAs in host cells generates mo...
The ongoing COVID-19 pandemic has increased awareness about sex-specific differences in immunity and outcomes following respiratory virus infections. Strong evidence of a male bias in COVID-...
Flaviviruses are pathogens of global public health concern. They include dengue virus (DENV), West Nile virus (WNV), and zika virus (ZIKV). There are no approved US Food and Drug Administrat...
Date: July 07, 2021 Time: 8:00am (PDT), 11:00am (EDT) The DNA damage response is extremely crucial in maintaining genomic integrity. Failure to repair damaged DNA can result in the propagati...
Date: August 26, 2021 Time: 7:00am (PDT), 10:00am (EDT) Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease with rising incidence and a remarkable resistance to current therapies. In t...
In this preliminary experiment, we used spatial transcriptomics to assess the gene expression profiles of microglia or astrocytes in relation to their distance from plaques. We compared 18-m...
Technological advances such as single-cell RNA sequencing accelerated our understanding of cellular diversity in tissues. However, the ability to elucidate this cellular heterogeneity while...
In 1910, Harrison published the first report of frog embryonic sympathetic ganglia grown in hanging drops of lymph for a few days, where single neurons extended nerve fibers with complex gro...
The increasing burden of neurological disorders as our population ages, together with the high personal and societal costs of mental and substance use disorders, underscores the need for new...
The misfolding of intrinsically disordered proteins (IDPs) such as tau and α-synuclein (αSyn) has been associated with the on-set and progression of Alzheimer’s (AD) and Pa...
Adolescence is a critical period for the developing brain, and binge drinking during this neuromaturation can result in enduring abnormal brain function and behavior. Repeated adolescent bin...
Learning Objectives: 1. Delineate the goals of studies of brain, computation and behavior and how they can be integrated. 2. Describe how neuromodulators such as oxytocin transform circuits...
Learning Objections: 1. To learn a new approach to understanding brain function by creating networks to perform tasks using machine learning. 2. To learn how how to probe these networks to d...
Cortical circuits often receive multiple inputs from upstream populations with non-overlapping stimulus tuning. Both the feedforward and recurrent architectures of the receiving cortical lay...
Multiscale modeling has arisen as a focus of computational systems biology, with the realization that genome, proteome, connectome, etceteromes, will only become comprehensible once placed i...
One role of theory is in guiding future experiments: What should we aim to measure? Which experimental results should we be surprised about? I will argue here that simple random networks mod...
Alzheimer’s and Parkinson’s diseases (AD, PD) are the two most common neurodegenerative disorders. Despite their debilitating effects and increasing prevalence in society, no cur...
DATE: August 19, 2020 TIME: 8:00am PT, 11:00pm ET Type 2 diabetes mellitus (T2D) is associated with an increased risk of osteoporotic fractures. Several factors have been identified as being...
Date: August 18, 2021 Time: 8:00am (PDT), 11:00am (EDT) Discover the tools to phenotype your NK cells and to perform functional analyses such as cellular cytotoxicity assays. From NK cell is...
Date: July 29, 2021 Time: 10:00am (PDT), 1:00pm (EDT) Experts are predicting an increase in influenza cases and a constant presence of SARS-CoV-2 in the shortly approaching influenza season....
Date: July 28, 2021 Time: 8:00am PDT Breast cancer is the most common form of cancer in women. It is estimated that 1 out of 8 women in the US will develop invasive breast cancer during her...
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