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Biomarkers Discovery
Biomarkers are molecules found in blood, body fluid, or tissue that denote a process or condition. Biomarkers are evaluated to see how the body is responding to a treatment or to access which treatment would be most optimal for a specific patient. Biomarker discovery describes the process of identifying new biomarkers to help promote health and well-being.
MAY 29, 2014 | 10:30 AM
Clinical laboratory information provides decision support for most healthcare providers and impacts care processes and patient outcomes throughout the entire health services delivery system....
MAY 29, 2014 | 7:30 AM
One of the major challenges to oncology based drug discovery and development has been the limited or incremental impact that many targeted agents have exhibited in the clinic. Understanding a...
MAR 20, 2014 | 1:00 PM
Using high throughput next-generation sequencing to simultaneously search large number of genes for pathogenic mutations has numerous advantages. It decreases the pressure to narrow the dif...
MAR 20, 2014 | 7:00 AM
Huntington's disease (HD) is a progressive, inherited, degenerative brain disorder that produces physical, mental and emotional changes. Named for George Huntington, the physician who fi...
MAR 19, 2014 | 1:00 PM
The Willerth lab investigates how to engineer neural tissue by combining pluripotent stem cells, controlled drug delivery and biomaterial scaffolds. When generating these replacement tissues,...
MAR 19, 2014 | 12:00 PM
Synaptic dysfunction and loss caused by age-dependent accumulation of synaptotoxic Amyloid beta (Abeta)1-42 oligomers is proposed to underlie cognitive decline in Alzheimers disease (AD). Syn...
MAR 19, 2014 | 10:00 AM
Neuron-glial interactions are increasingly recognized as being key for physiological and pathological processes in the central nervous system. Microglia have been found to play a causal role...
FEB 19, 2014 | 9:00 AM
Genome sequencing technologies have enabled a rapid expansion into understanding cancer biology, drug development, and treatment resistance. Research in our laboratory has focused on the app...
FEB 05, 2014 | 11:00 AM
C.E. CREDITS
Non-surgical transfer techniques for mouse embryos and sperm provide animal welfare benefits for assisted reproduction of mice. While surgical embryo transfer (ET) is an effective method for...
OCT 17, 2013 | 12:00 PM
The discovery of proteinaceous disease biomarkers and their clinical validation is critically important for the enablement of molecular diagnostics and ultimately, precision medicine. In spit...
OCT 17, 2013 | 11:00 AM
C.E. CREDITS
Curative therapy for metastatic disease in solid malignancies remains frustratingly elusive due to the long recognized problem of tumor cell heterogeneity and emergence of treatment resistant...
OCT 17, 2013 | 7:00 AM
RNA-Seq allows the simultaneous observation of gene expression levels, mutations in the coding sequences, splice variants and gene fusions, which are especially important in cancer studies. A...
OCT 16, 2013 | 12:00 PM
The effective implementation of personalised cancer therapeutic regimens depends on the successful identification and translation of informative biomarkers to aid clinical decision making. Th...
OCT 16, 2013 | 10:00 AM
C.E. CREDITS
The current paradigm of detecting established cancer (often too late) and treating routinely with cytotoxic drugs is beginning to change. Advanced technologies such as whole genome sequencin...
AUG 22, 2013 | 7:00 AM
Rheumatoid Arthritis (RA) is a heterogenous disease that affects 1.5% of the population. Similar to cancer, early detection coupled with an effective treatment strategy can significantly impr...
AUG 21, 2013 | 4:00 PM
C.E. CREDITS
Approximately 98% of the human genome comprises noncoding DNA, the function of which is largely unknown. Intriguingly, more than 85% of single nucleotide polymorphisms identified to be associ...
AUG 21, 2013 | 2:00 PM
Increasingly genome sequence knowledge is unraveling the complexity of rare Mendelian disorders offering hope for our children's medical care through better disease diagnosis and ultimately p...
AUG 21, 2013 | 12:00 PM
C.E. CREDITS
Susceptibility to coronary artery disease (CAD) is claimed to be 40% to 60% inherited, but until recently genetic risk factors predisposing to CAD have been elusive. Comprehensive prevention...
OCT 26, 2011 | 2:00 PM
Autophagy is a normal degradative pathway that involves the sequestration of entire organelles, protein complexes, and misfolded proteins in a membrane vacuole called the autophagosome. The ...
MAR 20, 2014 | 1:00 PM
Using high throughput next-generation sequencing to simultaneously search large number of genes for pathogenic mutations has numerous advantages. It decreases the pressure to narrow the dif...
MAR 20, 2014 | 7:00 AM
Huntington's disease (HD) is a progressive, inherited, degenerative brain disorder that produces physical, mental and emotional changes. Named for George Huntington, the physician who fi...
MAR 19, 2014 | 1:00 PM
The Willerth lab investigates how to engineer neural tissue by combining pluripotent stem cells, controlled drug delivery and biomaterial scaffolds. When generating these replacement tissues,...
MAR 19, 2014 | 12:00 PM
Synaptic dysfunction and loss caused by age-dependent accumulation of synaptotoxic Amyloid beta (Abeta)1-42 oligomers is proposed to underlie cognitive decline in Alzheimers disease (AD). Syn...
MAR 19, 2014 | 10:00 AM
Neuron-glial interactions are increasingly recognized as being key for physiological and pathological processes in the central nervous system. Microglia have been found to play a causal role...
FEB 19, 2014 | 9:00 AM
Genome sequencing technologies have enabled a rapid expansion into understanding cancer biology, drug development, and treatment resistance. Research in our laboratory has focused on the app...
FEB 05, 2014 | 11:00 AM
C.E. CREDITS
Non-surgical transfer techniques for mouse embryos and sperm provide animal welfare benefits for assisted reproduction of mice. While surgical embryo transfer (ET) is an effective method for...