Cancer Therapeutics: Cancer is often treated by surgery, chemotherapy, radiation therapy, targeted therapy (including immunotherapy such as monoclonal antibody therapy), hormonal therapy, and synthetic lethality. The choice of therapy depends upon the stage of the disease, and the location and grade of the tumor, as well as the patient's general status. Many clinical trial cancer treatments are also under development.
The first small molecule inhibitor of the molecular chaperone Heat Shock Protein 90 (HSP90) was identified more than 20 years ago. Upon determination of the drug binding site and clarificatio...
DATE: October 10, 2017TIME: 9:00AM PDTPatient-derived xenografts (PDX) are increasingly being used in biomedical research for therapeutic analysis in mice. Unlike traditional cell line...
DATE: October 4th, 2017TIME: 8:00AM PT, 11:00AM ET, 5:00PM (GMT+2)New HCV drugs are now approved which, when used in combination, yield very high rates of cure of HC...
DATE: September 28, 2017TIME: 10:00am PDT, 1:00pm EDT The use of gene therapy is well studied due to its potential to treat cancer, the second leading cause of death worldwide....
To study cell metabolism, our laboratory has found it exceedingly informative to integrate Agilent Seahorse XF Analyzers with mass spectrometry-based measurements of metabolomics and stable i...
DATE: September 19, 2017TIME: 10:30am PDT/ 1:30pm EDT/ 7:30pm CESTPart 1 – Cigall Kadoch, Ph.D. (30 min.)Exome- and genome-wide sequencing studies in human cancer have...
The human large intestine houses trillions of microorganisms which collectively form the highly diverse microbial community known as the gut microbiota. The gut microbiota performs many funct...
DATE: September 7, 2017TIME: 9:00AM PT, 12:00PM ETThe success of immune checkpoint blockade adds a new therapeutic category to the cancer therapy repertoire. Despite efforts made on can...
Regenerative medicine therapeutics aimed at restoring normal cell function due to trauma and disease are gaining increasing momentum in clinical trials. For this purpose, lentivirus-based gen...
The identity of somatic and pluripotent cells can be epigenetically reprogrammed and forced to adapt a new functional cell state by different methods and distinct combinations of exogenous fa...
DATE: June 28, 2017TIME: 7:00am PT, 10am ETAs gene therapy approaches usually require large amounts of AAV vectors for clinical use, few manufacturing processes have been repo...
Acoustic dispensing technology has allowed for compound plating to be highly customizable depending upon scientific needs. The ability to dispense compounds from a single well to any we...
The realization of the promise of personalized molecular medicine requires efficient development and implementation of novel targeted therapeutics linked to molecular markers able to identify...
CALIXAR has developed an innovative detergent/surfactant based approach consisting on native isolation and stabilization of therapeutic membrane protein targets such as GPCRs, ion channels, t...
DATE: May 9th, 2017TIME: 10:00AM PDT, 1:00PM ETMyeloproliferative neoplasms including myelofibrosis (MF) are characterized by anemia, splenomegaly, bone marrow fibrosis and inflammatory...
DATE: May 2, 2017TIME: 8:00am PT, 11:00am ET, 4:00pm GMT, 5:00pm CETThe natural immune responses that patients develop to their own tumors, as well as therapeutic regimens employin...
DATE: April 20th, 2017TIME: 10:00AM SGT, 11:00AM KST, 12:00PM AEST, 2:00PM NZSTWith increasing breadth and depth of genomics studies across a range of cancers, it is now apparent that t...
Endometrial cancer is the most common gynecologic malignancy in the United States and both the incidence and associated mortality are rising. When detected early, endometrial cancer survival...
G protein coupled receptors (GPCRs) are the targets of 30-40% of all approved drugs. However many approaches successfully applied to drug discovery for soluble protein targets have made a lim...
Cell growth and regulation involve vast networks of interacting DNAs, RNAs, proteins, lipids and sugars. Through a fundamental strategy of life, these interactions push multiple cellular proc...
Much has been made in the popular press about importance of our "genes" in everything from our weight, intelligence, and our risk of disease. While there is a scientific basis...
Gastrointestinal (GI) disorders are now widely recognized as a clinical symptom of autism spectrum disorder (ASD), and research into the microbiome-gut-brain axis is beginning to reveal the i...
The starting point for an interaction between a patient and a clinician is almost always a set of clinical facts (aka a phenotype). Phenotype-first medicine is the standard way in which the p...
The first small molecule inhibitor of the molecular chaperone Heat Shock Protein 90 (HSP90) was identified more than 20 years ago. Upon determination of the drug binding site and clarificatio...
DATE: October 10, 2017TIME: 9:00AM PDTPatient-derived xenografts (PDX) are increasingly being used in biomedical research for therapeutic analysis in mice. Unlike traditional cell line...
DATE: October 4th, 2017TIME: 8:00AM PT, 11:00AM ET, 5:00PM (GMT+2)New HCV drugs are now approved which, when used in combination, yield very high rates of cure of HC...
DATE: September 28, 2017TIME: 10:00am PDT, 1:00pm EDT The use of gene therapy is well studied due to its potential to treat cancer, the second leading cause of death worldwide....
To study cell metabolism, our laboratory has found it exceedingly informative to integrate Agilent Seahorse XF Analyzers with mass spectrometry-based measurements of metabolomics and stable i...
DATE: September 19, 2017TIME: 10:30am PDT/ 1:30pm EDT/ 7:30pm CESTPart 1 – Cigall Kadoch, Ph.D. (30 min.)Exome- and genome-wide sequencing studies in human cancer have...
The human large intestine houses trillions of microorganisms which collectively form the highly diverse microbial community known as the gut microbiota. The gut microbiota performs many funct...
DATE: September 7, 2017TIME: 9:00AM PT, 12:00PM ETThe success of immune checkpoint blockade adds a new therapeutic category to the cancer therapy repertoire. Despite efforts made on can...
Regenerative medicine therapeutics aimed at restoring normal cell function due to trauma and disease are gaining increasing momentum in clinical trials. For this purpose, lentivirus-based gen...
The identity of somatic and pluripotent cells can be epigenetically reprogrammed and forced to adapt a new functional cell state by different methods and distinct combinations of exogenous fa...
DATE: June 28, 2017TIME: 7:00am PT, 10am ETAs gene therapy approaches usually require large amounts of AAV vectors for clinical use, few manufacturing processes have been repo...
Acoustic dispensing technology has allowed for compound plating to be highly customizable depending upon scientific needs. The ability to dispense compounds from a single well to any we...
The realization of the promise of personalized molecular medicine requires efficient development and implementation of novel targeted therapeutics linked to molecular markers able to identify...
CALIXAR has developed an innovative detergent/surfactant based approach consisting on native isolation and stabilization of therapeutic membrane protein targets such as GPCRs, ion channels, t...
DATE: May 9th, 2017TIME: 10:00AM PDT, 1:00PM ETMyeloproliferative neoplasms including myelofibrosis (MF) are characterized by anemia, splenomegaly, bone marrow fibrosis and inflammatory...
DATE: May 2, 2017TIME: 8:00am PT, 11:00am ET, 4:00pm GMT, 5:00pm CETThe natural immune responses that patients develop to their own tumors, as well as therapeutic regimens employin...
DATE: April 20th, 2017TIME: 10:00AM SGT, 11:00AM KST, 12:00PM AEST, 2:00PM NZSTWith increasing breadth and depth of genomics studies across a range of cancers, it is now apparent that t...
Endometrial cancer is the most common gynecologic malignancy in the United States and both the incidence and associated mortality are rising. When detected early, endometrial cancer survival...
G protein coupled receptors (GPCRs) are the targets of 30-40% of all approved drugs. However many approaches successfully applied to drug discovery for soluble protein targets have made a lim...
Cell growth and regulation involve vast networks of interacting DNAs, RNAs, proteins, lipids and sugars. Through a fundamental strategy of life, these interactions push multiple cellular proc...
Much has been made in the popular press about importance of our "genes" in everything from our weight, intelligence, and our risk of disease. While there is a scientific basis...
Gastrointestinal (GI) disorders are now widely recognized as a clinical symptom of autism spectrum disorder (ASD), and research into the microbiome-gut-brain axis is beginning to reveal the i...
The starting point for an interaction between a patient and a clinician is almost always a set of clinical facts (aka a phenotype). Phenotype-first medicine is the standard way in which the p...
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