Cell imaging: encloses the techniques that allow the detection and analysis of cellular organelles and macromolecules. Live cell imaging was pioneered in the first decade of the 20th century, and is used by scientists to obtain a better understanding of biological function through the study of cellular dynamics.
A fundamental challenge in developing brain machine interfaces (BMIs) is building a decoder between patterns of brain activity and movement in patients with spinal cord injury, ALS, and amput...
Working memory ability matures late in life, in adolescence or early adulthood, and may be enhanced even in adulthood through cognitive training. The mechanisms through which working memory i...
Miniaturized microscopes in combination with genetically encoded calcium indicators now allow recordings of activity from hundreds of neurons simultaneously in freely moving animals. We are b...
Gilles de la Tourette syndrome (GTS) is a neurodevelopmental disorder exhibiting both motor and behavioral impairment. Like most neuropsychiatric disorders, its pathophysiology has yet to be...
Basal forebrain cholinergic inputs to the cortex are known to contribute to attentional performance. A major focus of my laboratory has been to study the receptors mediating the effects of ac...
Dr. Kasthuri is a Neuroscience Researcher at Argonne National Labs and an Assistant Professor (adjunct) in the Dept. of Neurobiology, University of Chicago. He has an MD from Washington...
The idea of schizophrenia typically conjures up images of people who hear voices, see visions and have delusional beliefs. However, clinicians have long recognized cognitive dysfunction as on...
Our decisions are governed by a balance between prospective instrumental goal-oriented and retrospective habitual learning strategies. This arbitration is relevant dimensionally across psychi...
Parkinson’s disease (PD) is characterized by the loss of dopamine and the disruption of brain circuits (basal ganglia and cortex) that are responsible for normal cognitive and motor per...
Sensorimotor integration is important for the acquisition and performance of motor skills. Here,we show the emergence of neuroplastic changes in the interactions between the motor andsomatose...
We are nearing three decades of research on the neural circuits of Pavlovian fear conditioning. The advent of new techniques such as genetic and optogenetic manipulations have greatly advance...
DATE: March 7, 2017TIME: 7:00AM PT, 10:00AM ET, 3:00PM GMTOrganoPlates® are a novel microfluidic culture platform enabling long-term, membrane-free 3D co-culture models in a mi...
Healthcare is becoming more proactive and data-rich than anything before possible – and will increasingly focus on maintaining and enhancing wellness more than just reacting to disease....
Cell growth and regulation involve vast networks of interacting DNAs, RNAs, proteins, lipids and sugars. Through a fundamental strategy of life, these interactions push multiple cellular proc...
In this era of precision molecular medicine, knowledge changes rapidly and is highly dispersed. Physicians and patients are faced with conflicting expert opinions and a shortage of acti...
Despite vast investment for decades in cancer research and development, cancer is still among the leading causes of death worldwide and its toll is expected to rise by about 70% over the next...
Clinical whole genome sequencing (cWGS) is rapidly gaining acceptance as cost is decreasing and success rates in identifying disease-causing variants are increasing. While the application of...
Although there have been enormous advances in gene sequencing, the results give massive amounts of data that only point to disease risk. Major health factors, including diet, lifestyle, envir...
Psychiatric disorders are among the leading causes of disability worldwide. One fifth of the population will suffer from a psychiatric disorder in their lifetime. Antipsychotic and antidepres...
Best practices for developing precision medicine diagnostics can include completing a retrospective analysis. Obtaining enough samples to have a statistically significant study typicall...
Liquid Biopsies are gaining acceptance in the Oncology community as a surrogate or complement to the gold standard of tissue biopsy. A liquid biopsy provides biomarker information that...
Biobanks are a powerful resource in the advancement of precision medicine, and integrating large scale genomics data across Biobank cohorts offer opportunities to further enhance and expedite...
In this talk, I will use examples from my research using big data analytics to define ideals of precision medicine and digital health across a variety of diseases. Specifically, I will i...
Challenges in achieving comparability, reproducibility and accuracy in biological assays has driven a demand for improved confidence in measurements that support development of regenerative m...
A fundamental challenge in developing brain machine interfaces (BMIs) is building a decoder between patterns of brain activity and movement in patients with spinal cord injury, ALS, and amput...
Working memory ability matures late in life, in adolescence or early adulthood, and may be enhanced even in adulthood through cognitive training. The mechanisms through which working memory i...
Miniaturized microscopes in combination with genetically encoded calcium indicators now allow recordings of activity from hundreds of neurons simultaneously in freely moving animals. We are b...
Gilles de la Tourette syndrome (GTS) is a neurodevelopmental disorder exhibiting both motor and behavioral impairment. Like most neuropsychiatric disorders, its pathophysiology has yet to be...
Basal forebrain cholinergic inputs to the cortex are known to contribute to attentional performance. A major focus of my laboratory has been to study the receptors mediating the effects of ac...
Dr. Kasthuri is a Neuroscience Researcher at Argonne National Labs and an Assistant Professor (adjunct) in the Dept. of Neurobiology, University of Chicago. He has an MD from Washington...
The idea of schizophrenia typically conjures up images of people who hear voices, see visions and have delusional beliefs. However, clinicians have long recognized cognitive dysfunction as on...
Our decisions are governed by a balance between prospective instrumental goal-oriented and retrospective habitual learning strategies. This arbitration is relevant dimensionally across psychi...
Parkinson’s disease (PD) is characterized by the loss of dopamine and the disruption of brain circuits (basal ganglia and cortex) that are responsible for normal cognitive and motor per...
Sensorimotor integration is important for the acquisition and performance of motor skills. Here,we show the emergence of neuroplastic changes in the interactions between the motor andsomatose...
We are nearing three decades of research on the neural circuits of Pavlovian fear conditioning. The advent of new techniques such as genetic and optogenetic manipulations have greatly advance...
DATE: March 7, 2017TIME: 7:00AM PT, 10:00AM ET, 3:00PM GMTOrganoPlates® are a novel microfluidic culture platform enabling long-term, membrane-free 3D co-culture models in a mi...
Healthcare is becoming more proactive and data-rich than anything before possible – and will increasingly focus on maintaining and enhancing wellness more than just reacting to disease....
Cell growth and regulation involve vast networks of interacting DNAs, RNAs, proteins, lipids and sugars. Through a fundamental strategy of life, these interactions push multiple cellular proc...
In this era of precision molecular medicine, knowledge changes rapidly and is highly dispersed. Physicians and patients are faced with conflicting expert opinions and a shortage of acti...
Despite vast investment for decades in cancer research and development, cancer is still among the leading causes of death worldwide and its toll is expected to rise by about 70% over the next...
Clinical whole genome sequencing (cWGS) is rapidly gaining acceptance as cost is decreasing and success rates in identifying disease-causing variants are increasing. While the application of...
Although there have been enormous advances in gene sequencing, the results give massive amounts of data that only point to disease risk. Major health factors, including diet, lifestyle, envir...
Psychiatric disorders are among the leading causes of disability worldwide. One fifth of the population will suffer from a psychiatric disorder in their lifetime. Antipsychotic and antidepres...
Best practices for developing precision medicine diagnostics can include completing a retrospective analysis. Obtaining enough samples to have a statistically significant study typicall...
Liquid Biopsies are gaining acceptance in the Oncology community as a surrogate or complement to the gold standard of tissue biopsy. A liquid biopsy provides biomarker information that...
Biobanks are a powerful resource in the advancement of precision medicine, and integrating large scale genomics data across Biobank cohorts offer opportunities to further enhance and expedite...
In this talk, I will use examples from my research using big data analytics to define ideals of precision medicine and digital health across a variety of diseases. Specifically, I will i...
Challenges in achieving comparability, reproducibility and accuracy in biological assays has driven a demand for improved confidence in measurements that support development of regenerative m...
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