While the "Jolie effect" has refocused attention on the central role of BRCA gene analyses in the diagnosis and prevention of hereditary breast and ovarian cancer, there is a global disparity...
Due to the large increase in the number and complexity of clinical laboratory tests, optimal use of laboratory testing services has presented many challenges. The Clinical Laboratory Integrat...
For the last 60 years the primary method of preventing cervical cancer in both the U.S. and Europe has been cervical cytology -- if it is negative, women are rescreen in three years and if po...
The therapeutic utility of stem cells is rooted in an understanding -- and exploitation -- of their natural role from earliest development to lifes end. Their job is first to participate in o...
Parkinsons disease is the most common neurodegenerative movement disorder. Over the past few years, studies have identified a number of genes that cause or contribute to the pathogenesis of t...
Using high throughput next-generation sequencing to simultaneously search large number of genes for pathogenic mutations has numerous advantages. It decreases the pressure to narrow the dif...
Neural stem cells exist in the adult mammalian brain throughout life. They reside in the subgranular layer of the dentate gyrus and in the subventricular zone. Neural stem cells have the capa...
Alzheimers disease (AD) is a common neurodegenerative disorder characterized clinically by progress decline in memory and thinking and pathologically by the presence of senile plaques and neu...
With a rising prevalence recently exceeding 1%, autism spectrum disorder (ASD) has become a pressing public health issue. Crucial hurdles on the way to targeted treatments are (i) the relianc...
Neuroimaging plays a large role in our pursuit of the understanding of behavior and cognition in health and disease. The past decade has seen the emergence of a wealth of resources that suppo...
The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is part of a new Presidential focus aimed at revolutionizing our understanding of the human brain. By acce...
The therapeutic utility of stem cells is rooted in an understanding -- and exploitation -- of their natural role from earliest development to lifes end. Their job is first to participate in o...
Huntington's disease (HD) is a progressive, inherited, degenerative brain disorder that produces physical, mental and emotional changes. Named for George Huntington, the physician who fi...
The brain is a complex, densely wired circuit made out of heterogeneous cells, which vary in their shapes, molecular composition, and patterns of connectivity. In order to help discover how n...
Connectomics is a new field of research that aims to map the synapses of the nervous system in order to construct a wiring diagram of all the neural circuits. It is necessary to use the elect...
ATP-binding cassette transporter A1 (ABCA1) mediates cholesterol efflux to lipid-free apolipoproteins such as apolipoprotein A-I (apoA-I) and apolipoprotein E (apoE). ABCA1 is essential regul...
We present a personalized medicine suite of software applications developed at UCSF for multiple sclerosis (MS): the MS Bioscreen. This new tool addresses the challenges of the dynamic manage...
Making precision cancer care a future reality requires novel approachesto finding treatment targets in cancers. Single-gene assays currently performed in clinical research laboratories are in...
The environment in which laboratory rodents are kept has an impact on experimental data and breeding performance. The quality of the environment is defined by both the quality of the primary...
The rise of zebrafish as a research model has been dramatic. Given the global nature of the work, the rise in shipping zebrafish as a laboratory species has been sharp. Up until this point th...
For the purpose of ensuring research integrity, data reproducibility, and animal welfare, institutions that conduct animal research have the responsibility to evaluate vendors that provide la...
Monitoring the health of laboratory rodents is an important tool for improving the quality of animals used in research. However not all animal facilities have the same requirements, and an ex...
While the "Jolie effect" has refocused attention on the central role of BRCA gene analyses in the diagnosis and prevention of hereditary breast and ovarian cancer, there is a global disparity...
Due to the large increase in the number and complexity of clinical laboratory tests, optimal use of laboratory testing services has presented many challenges. The Clinical Laboratory Integrat...
For the last 60 years the primary method of preventing cervical cancer in both the U.S. and Europe has been cervical cytology -- if it is negative, women are rescreen in three years and if po...
The therapeutic utility of stem cells is rooted in an understanding -- and exploitation -- of their natural role from earliest development to lifes end. Their job is first to participate in o...
Parkinsons disease is the most common neurodegenerative movement disorder. Over the past few years, studies have identified a number of genes that cause or contribute to the pathogenesis of t...
Using high throughput next-generation sequencing to simultaneously search large number of genes for pathogenic mutations has numerous advantages. It decreases the pressure to narrow the dif...
Neural stem cells exist in the adult mammalian brain throughout life. They reside in the subgranular layer of the dentate gyrus and in the subventricular zone. Neural stem cells have the capa...
Alzheimers disease (AD) is a common neurodegenerative disorder characterized clinically by progress decline in memory and thinking and pathologically by the presence of senile plaques and neu...
With a rising prevalence recently exceeding 1%, autism spectrum disorder (ASD) has become a pressing public health issue. Crucial hurdles on the way to targeted treatments are (i) the relianc...
Neuroimaging plays a large role in our pursuit of the understanding of behavior and cognition in health and disease. The past decade has seen the emergence of a wealth of resources that suppo...
The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is part of a new Presidential focus aimed at revolutionizing our understanding of the human brain. By acce...
The therapeutic utility of stem cells is rooted in an understanding -- and exploitation -- of their natural role from earliest development to lifes end. Their job is first to participate in o...
Huntington's disease (HD) is a progressive, inherited, degenerative brain disorder that produces physical, mental and emotional changes. Named for George Huntington, the physician who fi...
The brain is a complex, densely wired circuit made out of heterogeneous cells, which vary in their shapes, molecular composition, and patterns of connectivity. In order to help discover how n...
Connectomics is a new field of research that aims to map the synapses of the nervous system in order to construct a wiring diagram of all the neural circuits. It is necessary to use the elect...
ATP-binding cassette transporter A1 (ABCA1) mediates cholesterol efflux to lipid-free apolipoproteins such as apolipoprotein A-I (apoA-I) and apolipoprotein E (apoE). ABCA1 is essential regul...
We present a personalized medicine suite of software applications developed at UCSF for multiple sclerosis (MS): the MS Bioscreen. This new tool addresses the challenges of the dynamic manage...
Making precision cancer care a future reality requires novel approachesto finding treatment targets in cancers. Single-gene assays currently performed in clinical research laboratories are in...
The environment in which laboratory rodents are kept has an impact on experimental data and breeding performance. The quality of the environment is defined by both the quality of the primary...
The rise of zebrafish as a research model has been dramatic. Given the global nature of the work, the rise in shipping zebrafish as a laboratory species has been sharp. Up until this point th...
For the purpose of ensuring research integrity, data reproducibility, and animal welfare, institutions that conduct animal research have the responsibility to evaluate vendors that provide la...
Monitoring the health of laboratory rodents is an important tool for improving the quality of animals used in research. However not all animal facilities have the same requirements, and an ex...