NIH representatives from the BRAIN Initiative will be presenting an overview of the NIH BRAIN Initiative and describing funding opportunity announcements (FOAs) supporting impacts in human ne...
Joshua Gordon, M.D., Ph.D., Director of the National Institute of Mental Health, will provide an overview of challenges and opportunities in mental health research. Dr. Gordon will present em...
Digitalization has transformed virtually every industry, but it has been slow to gain traction within the preclinical phase of the drug development journey. Recent advances in digital vivariu...
For 100 years the cannabis plant has been demonized, made illegal, and kept from researchers. Recently, states have begun to take the situation into their own hands, enabling patients to...
Clathrin mediated endocytosis (CME) at pre-synaptic terminals is functionally coupled to neuro-transmitter release. Like other cytosolic proteins, clathrin is synthesized in cell-bodies and c...
Most neuropsychiatric diseases involve multifactorial systems characterized by complex interactions among genetic predisposition/resiliency, environmental/social determinants, molecular seque...
Biomedical research depends on the use of model systems to explore basic biology, probe disease mechanisms, and conduct drug discovery and development. However, results from such systems are...
The cerebellum is incorporated into the distributed neural circuits subserving motor control, cognitive processing and the modulation of emotion. This lecture provides an overview of anatomic...
98% of small molecules and 100% of large molecules do not cross the blood-brain barrier (BBB). Biologics, including therapeutic antibodies (e.g. anti-amyloid antibodies), have been at the for...
Complex animal behavior is produced by dynamic interactions between discrete regions of the brain. As such, defining functional connections between brain regions is critical in gaining a full...
Psychiatric diagnosis is inherently difficult, due to the lack of clear biomarkers or any other objective assessment. Although quantitative, the psychometric scales employed during the psychi...
Conspecific aggression is a common problem amongst laboratory housed male mice. While C57BL/6 are not the most aggressive strain we house, they are exceedingly common, and dealing with...
There is a considerable interest and need for evidence-based recommendations regarding the social housing of laboratory rabbits. This presentation will review the principles surrounding the s...
Recent advances in flow and mass cytometry have greatly expanded the number of immune cell parameters that can be interrogated, resulting in an improved understanding of the immune system het...
Males and females differ in their immunological responses to viral and vaccine antigens, with females typically mounting higher immune responses than males. These sex-based immunological diff...
Studying the genetics of rare congenital disorders disrupting cognitive function has led to the identification of multiple disease genes that helped us better understand the mechanisms underl...
Alterations in homeostatic functions such as energy balance and sleep patterns are frequently seen in the elderly and these changes may precede and predict subsequent cognitive decline. ...
As we experience our environments, our brains are constantly computing inferences about the most likely state of the world: Are those lights in the distance headlights or streetlights? ...
Epigenetics refers to the study of nuclear architecture and gene regulation. Epigenetic mechanisms govern many physiological processes such as cell differentiation, x-inactivation, and genomi...
Specialized aggregations of extracellular matrix called perineuronal nets (PNNs) appear during juvenile stages of development and surround primarily fast-spiking, parvalbumin (PV)-containing...
Working memory ability matures late in life, in adolescence or early adulthood, and may be enhanced even in adulthood through cognitive training. The mechanisms through which working memory i...
A fundamental challenge in developing brain machine interfaces (BMIs) is building a decoder between patterns of brain activity and movement in patients with spinal cord injury, ALS, and amput...
Miniaturized microscopes in combination with genetically encoded calcium indicators now allow recordings of activity from hundreds of neurons simultaneously in freely moving animals. We are b...
NIH representatives from the BRAIN Initiative will be presenting an overview of the NIH BRAIN Initiative and describing funding opportunity announcements (FOAs) supporting impacts in human ne...
Joshua Gordon, M.D., Ph.D., Director of the National Institute of Mental Health, will provide an overview of challenges and opportunities in mental health research. Dr. Gordon will present em...
Digitalization has transformed virtually every industry, but it has been slow to gain traction within the preclinical phase of the drug development journey. Recent advances in digital vivariu...
For 100 years the cannabis plant has been demonized, made illegal, and kept from researchers. Recently, states have begun to take the situation into their own hands, enabling patients to...
Clathrin mediated endocytosis (CME) at pre-synaptic terminals is functionally coupled to neuro-transmitter release. Like other cytosolic proteins, clathrin is synthesized in cell-bodies and c...
Most neuropsychiatric diseases involve multifactorial systems characterized by complex interactions among genetic predisposition/resiliency, environmental/social determinants, molecular seque...
Biomedical research depends on the use of model systems to explore basic biology, probe disease mechanisms, and conduct drug discovery and development. However, results from such systems are...
The cerebellum is incorporated into the distributed neural circuits subserving motor control, cognitive processing and the modulation of emotion. This lecture provides an overview of anatomic...
98% of small molecules and 100% of large molecules do not cross the blood-brain barrier (BBB). Biologics, including therapeutic antibodies (e.g. anti-amyloid antibodies), have been at the for...
Complex animal behavior is produced by dynamic interactions between discrete regions of the brain. As such, defining functional connections between brain regions is critical in gaining a full...
Psychiatric diagnosis is inherently difficult, due to the lack of clear biomarkers or any other objective assessment. Although quantitative, the psychometric scales employed during the psychi...
Conspecific aggression is a common problem amongst laboratory housed male mice. While C57BL/6 are not the most aggressive strain we house, they are exceedingly common, and dealing with...
There is a considerable interest and need for evidence-based recommendations regarding the social housing of laboratory rabbits. This presentation will review the principles surrounding the s...
Recent advances in flow and mass cytometry have greatly expanded the number of immune cell parameters that can be interrogated, resulting in an improved understanding of the immune system het...
Males and females differ in their immunological responses to viral and vaccine antigens, with females typically mounting higher immune responses than males. These sex-based immunological diff...
Studying the genetics of rare congenital disorders disrupting cognitive function has led to the identification of multiple disease genes that helped us better understand the mechanisms underl...
Alterations in homeostatic functions such as energy balance and sleep patterns are frequently seen in the elderly and these changes may precede and predict subsequent cognitive decline. ...
As we experience our environments, our brains are constantly computing inferences about the most likely state of the world: Are those lights in the distance headlights or streetlights? ...
Epigenetics refers to the study of nuclear architecture and gene regulation. Epigenetic mechanisms govern many physiological processes such as cell differentiation, x-inactivation, and genomi...
Specialized aggregations of extracellular matrix called perineuronal nets (PNNs) appear during juvenile stages of development and surround primarily fast-spiking, parvalbumin (PV)-containing...
Working memory ability matures late in life, in adolescence or early adulthood, and may be enhanced even in adulthood through cognitive training. The mechanisms through which working memory i...
A fundamental challenge in developing brain machine interfaces (BMIs) is building a decoder between patterns of brain activity and movement in patients with spinal cord injury, ALS, and amput...
Miniaturized microscopes in combination with genetically encoded calcium indicators now allow recordings of activity from hundreds of neurons simultaneously in freely moving animals. We are b...
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