Disease modeling is the use of a disease model, which is an animal or cells containing all or some of the pathological characteristics and mechanisms of a disease, to study that particular disease.
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Cancer initiation and virulence depends on mechanisms to evade host immunosurveillance and suppression of early invasion and growth. Distinct phenotypes of the immune infiltrates in and arou...
A recently proposed model for the incorporation of xenobiotics of clinical and forensic interest into the human skeleton suggests nerve agent metabolites may incorporate into bone at relativ...
Background: Acute myeloid leukemia (AML) is a molecularly and clinically heterogeneous hematological malignancy. Despite recent advancements in the treatment of AML, approximately 50% of pat...
Background: CDK4/6 inhibitors increase tumor immunogenicity in preclinical models of breast cancer and several trials combining CDK4/6 inhibitors and anti-PD1/PDL1 therapies are underway. Ho...
The basic units of biological structure and function are cells, which exhibit wide variation in regard to both type and state. We assess such variation by simultaneously profiling the transc...