Personalized medicine is practiced when doctors consider specific information of an individual patient when planning a course of treatment. In oncology, personalized medicine can include an understanding of the genetic profile of the cancer as well as clinical and demographic factors of the patient. Personalized cancer medicine can the potential to help individual patients and also develop novel, effective cancer therapeutics.
One of the primary goals of precision medicine is the aggregation and interpretation of deep, longitudinal patient-specific data in the context of the digital universe of information, using a...
Understanding disease at a deeper level so that it can be targeted more precisely is the essence of precision medicine. Rapid technological advance, particularly in genomics and sensor-based...
The use of laboratory animals requires education and training of persons who are to design and/or perform animal experiments. It is essential for these persons to practice various procedures...
Reproducibility refers to the ability of an experiment or study to be replicated, either by the same person or group or by others working independently. With regard to scientific public...
Quality animal research is based on quality animal care and use. This is achieved by coordinating several key personnel and activities, and implementing appropriate animal care and use proced...
Stage IV melanoma carried a 24 month life expectancy three short years ago. That is what T.J. Sharpe’s first oncologist told him he was facing, after a visit to the ER for a fever turne...
The management of prostate cancer (PCa) continues to evolve and does so at a rapid rate. Research and technological developments continue to refine our definitions and management of this comp...
Matching the mutational profile of a patient's tumor with appropriate targeted agents is a goal of personalized medicine in oncology. The number of FDA-approved targeted therapies, as well as...
In Chile, the regulatory context regarding animal use in research is very poor. A legal framework for Animal Care and Use Committees is practically nonexistent. Also, the chilean culture play...
Some commonly accepted principles of biosafety include the strict adherence to standard laboratory practices and techniques, the use of safety equipment such as primary barriers and personal...
Although the incidence of breast cancer is steadily increasing, mortality rates are decreasing. This means that the majority of women with breast cancer now survive, making it even more impor...
Over the last decade we have witnessed tremendous advances in our understanding of the underlying molecular alterations in human cancer. This has stimulated excitement for our ability to deve...
Survival rates for early stage non-small cell lung cancer (NSCLC) remain unacceptably low compared to other common solid tumors. This mortality reflects a weakness in conventional staging, as...
Patient-derived xenograft (PDX) models can recapitulate patient tumor histopathology, mutational status, gene expression patterns, and drug response with remarkable fidelity. At The Jackson L...
This presentation will focus on NuMediis general approach towards the discovery of new therapeutic uses for existing drugs. While the business models for repurposing marketed drugs versus rep...
While the "Jolie effect" has refocused attention on the central role of BRCA gene analyses in the diagnosis and prevention of hereditary breast and ovarian cancer, there is a global disparity...
The 2011 Guide for the Care and Use of Laboratory Animals has required that institutions place importance on assuring that staff working with animals are trained and competent to perform thei...
Simplifying Rodent Surgery... Tips for improving technique without incurring unreasonable costs Good science is greatly dependent on minimization of study variables. Surgery has the potential...
The discovery of proteinaceous disease biomarkers and their clinical validation is critically important for the enablement of molecular diagnostics and ultimately, precision medicine. In spit...
Curative therapy for metastatic disease in solid malignancies remains frustratingly elusive due to the long recognized problem of tumor cell heterogeneity and emergence of treatment resistant...
Survival rates for early stage non-small cell lung cancer (NSCLC) remain unacceptably low compared to other common solid tumors. This mortality reflects a weakness in conventional staging, a...
The current paradigm of detecting established cancer (often too late) and treating routinely with cytotoxic drugs is beginning to change. Advanced technologies such as whole genome sequencin...
One of the primary goals of precision medicine is the aggregation and interpretation of deep, longitudinal patient-specific data in the context of the digital universe of information, using a...
Understanding disease at a deeper level so that it can be targeted more precisely is the essence of precision medicine. Rapid technological advance, particularly in genomics and sensor-based...
The use of laboratory animals requires education and training of persons who are to design and/or perform animal experiments. It is essential for these persons to practice various procedures...
Reproducibility refers to the ability of an experiment or study to be replicated, either by the same person or group or by others working independently. With regard to scientific public...
Quality animal research is based on quality animal care and use. This is achieved by coordinating several key personnel and activities, and implementing appropriate animal care and use proced...
Stage IV melanoma carried a 24 month life expectancy three short years ago. That is what T.J. Sharpe’s first oncologist told him he was facing, after a visit to the ER for a fever turne...
The management of prostate cancer (PCa) continues to evolve and does so at a rapid rate. Research and technological developments continue to refine our definitions and management of this comp...
Matching the mutational profile of a patient's tumor with appropriate targeted agents is a goal of personalized medicine in oncology. The number of FDA-approved targeted therapies, as well as...
In Chile, the regulatory context regarding animal use in research is very poor. A legal framework for Animal Care and Use Committees is practically nonexistent. Also, the chilean culture play...
Some commonly accepted principles of biosafety include the strict adherence to standard laboratory practices and techniques, the use of safety equipment such as primary barriers and personal...
Although the incidence of breast cancer is steadily increasing, mortality rates are decreasing. This means that the majority of women with breast cancer now survive, making it even more impor...
Over the last decade we have witnessed tremendous advances in our understanding of the underlying molecular alterations in human cancer. This has stimulated excitement for our ability to deve...
Survival rates for early stage non-small cell lung cancer (NSCLC) remain unacceptably low compared to other common solid tumors. This mortality reflects a weakness in conventional staging, as...
Patient-derived xenograft (PDX) models can recapitulate patient tumor histopathology, mutational status, gene expression patterns, and drug response with remarkable fidelity. At The Jackson L...
This presentation will focus on NuMediis general approach towards the discovery of new therapeutic uses for existing drugs. While the business models for repurposing marketed drugs versus rep...
While the "Jolie effect" has refocused attention on the central role of BRCA gene analyses in the diagnosis and prevention of hereditary breast and ovarian cancer, there is a global disparity...
The 2011 Guide for the Care and Use of Laboratory Animals has required that institutions place importance on assuring that staff working with animals are trained and competent to perform thei...
Simplifying Rodent Surgery... Tips for improving technique without incurring unreasonable costs Good science is greatly dependent on minimization of study variables. Surgery has the potential...
The discovery of proteinaceous disease biomarkers and their clinical validation is critically important for the enablement of molecular diagnostics and ultimately, precision medicine. In spit...
Curative therapy for metastatic disease in solid malignancies remains frustratingly elusive due to the long recognized problem of tumor cell heterogeneity and emergence of treatment resistant...
Survival rates for early stage non-small cell lung cancer (NSCLC) remain unacceptably low compared to other common solid tumors. This mortality reflects a weakness in conventional staging, a...
The current paradigm of detecting established cancer (often too late) and treating routinely with cytotoxic drugs is beginning to change. Advanced technologies such as whole genome sequencin...
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