Protein Expression: Protein expression refers to the way in which proteins are synthesized, modified and regulated in living organisms. Inprotein research, the term can apply to either the object of study or the laboratory techniques required to manufactureproteins. This article focuses on the latter meaning of protein expression.
Understanding disease at a deeper level so that it can be targeted more precisely is the essence of precision medicine. Rapid technological advance, particularly in genomics and sensor-based...
In December 2012 the UK Prime Minister announced the 100,000 genomes project to introduce whole genome sequencing for treatment into the UK National Health Service (NHS) o...
Precision medicine promises a more effective approach to disease treatment and management. It is based on analyzing mutations of disease samples to unlock mechanisms of disease development an...
Personalised Healthcare is essential to AstraZeneca’s approach to drug development and is adopted by more than 80% of drug products in clinical development. Selection of the right patie...
DATE: February 2nd, 2016
TIME: 9am pacific time, 12pm eastern time
What is the most appropriate technology to empower your research?
Next generation sequencing (NGS) for RN...
DATE: January 15, 2016
TIME: 7am EST, 12pm UK, 1pm CET
With an increasing number of biomarkers and, often, limited availability of biopsy material, there is a growing need for multiplexed...
DATE: October 28th, 2015TIME: 11am Pacific time, 2pm Eastern timeNew discoveries uncover that exposure to current environmental, dietary, behavioral, and medical conditions can significantly...
Date: June 16, 2015Time: 8:00AM Pacific time, 11:00AM Eastern TimeGroup 2 innate lymphoid cells (ILC2s) are recently described innate immune cells that contribute to type 2 inflammation, tiss...
Over the past few years, evidence has been accumulating to indicate that ribosomal subunits are not simply tape-heads that decode mRNA sequences into polypeptide chains, but that they also pl...
I will discuss the use of genomic technologies - mostly ultrahigh-throughput DNA sequencing - to study normal human biology and to determine what goes wrong when we have disease. First I wil...
Perhaps the greatest surprise of genetic studies of human disease is that 90% of top-scoring disease-associated loci lie outside protein-coding regions. This has increased the urgency of mapp...
Cancers exhibit abnormal molecular signatures associated with disease initiation and progression. Molecular signatures could improve cancer screening, detection, drug development and selectio...
Please click here to watch this webinar On DemandsiRNA-mediated silencing of gene expression has revolutionized the study of biology by enabling rapid and unbiased loss-of-function studies to...
Laboratory animal surgical models are instrumental in biomedical research; therefore establishing healthy defined animal models is crucial to this research. Surgical procedures produce metab...
 Single-cell analysis is one of the most rapidly growing fields in biomedical research that is significantly expanding our understanding on the biologic characteristics of various diseases. F...
Mass spectrometry (MS)-based profiling of clinical specimens has been increasingly used in cancer research to characterize changes in protein expression between tumor and healthy tissue or be...
Advances in genomic research have led to identification of the majority of the drivers of tumor progression. However, our understanding of the molecular mechanisms propelling tumor growth is...
When the BCR/ABL1 fusion protein was identified in chronic myelogenous leukemia and the JAK2 V617F mutation was identified in patients with other myeloproliferative neoplasms (MPNs) such as p...
Human malignant glioma is a uniformly fatal disease, causing over 14,000 deaths in the US this year. Adults diagnosed with malignant brain tumors have a median survival of approximately 15 mo...
Understanding how genes coordinate their expression across cells in a growing embryo can provide insights into the transcriptional programs that control development. Intercellular variability...
The flexibility of the BioMark Real-Time PCR System, allow us to preform genetic research using different types of nano-fluidic (48.48 or 96.96) chips setup, in the thermal cycle of these chi...
The ENCODE and modENCODE consortia have generated a resource containing large amounts of transcriptomic data, extensive mapping of chromatin states, as well as the binding locations of >30...
The human genome encodes ~21,500 proteins that are subject to reversible phosphorylation at nearly 1 million phosphosites by about 538 protein kinases and 156 protein phosphatases. Amongst ot...
ATP-binding cassette transporter A1 (ABCA1) mediates cholesterol efflux to lipid-free apolipoproteins such as apolipoprotein A-I (apoA-I) and apolipoprotein E (apoE). ABCA1 is essential regul...
Understanding disease at a deeper level so that it can be targeted more precisely is the essence of precision medicine. Rapid technological advance, particularly in genomics and sensor-based...
In December 2012 the UK Prime Minister announced the 100,000 genomes project to introduce whole genome sequencing for treatment into the UK National Health Service (NHS) o...
Precision medicine promises a more effective approach to disease treatment and management. It is based on analyzing mutations of disease samples to unlock mechanisms of disease development an...
Personalised Healthcare is essential to AstraZeneca’s approach to drug development and is adopted by more than 80% of drug products in clinical development. Selection of the right patie...
DATE: February 2nd, 2016
TIME: 9am pacific time, 12pm eastern time
What is the most appropriate technology to empower your research?
Next generation sequencing (NGS) for RN...
DATE: January 15, 2016
TIME: 7am EST, 12pm UK, 1pm CET
With an increasing number of biomarkers and, often, limited availability of biopsy material, there is a growing need for multiplexed...
DATE: October 28th, 2015TIME: 11am Pacific time, 2pm Eastern timeNew discoveries uncover that exposure to current environmental, dietary, behavioral, and medical conditions can significantly...
Date: June 16, 2015Time: 8:00AM Pacific time, 11:00AM Eastern TimeGroup 2 innate lymphoid cells (ILC2s) are recently described innate immune cells that contribute to type 2 inflammation, tiss...
Over the past few years, evidence has been accumulating to indicate that ribosomal subunits are not simply tape-heads that decode mRNA sequences into polypeptide chains, but that they also pl...
I will discuss the use of genomic technologies - mostly ultrahigh-throughput DNA sequencing - to study normal human biology and to determine what goes wrong when we have disease. First I wil...
Perhaps the greatest surprise of genetic studies of human disease is that 90% of top-scoring disease-associated loci lie outside protein-coding regions. This has increased the urgency of mapp...
Cancers exhibit abnormal molecular signatures associated with disease initiation and progression. Molecular signatures could improve cancer screening, detection, drug development and selectio...
Please click here to watch this webinar On DemandsiRNA-mediated silencing of gene expression has revolutionized the study of biology by enabling rapid and unbiased loss-of-function studies to...
Laboratory animal surgical models are instrumental in biomedical research; therefore establishing healthy defined animal models is crucial to this research. Surgical procedures produce metab...
 Single-cell analysis is one of the most rapidly growing fields in biomedical research that is significantly expanding our understanding on the biologic characteristics of various diseases. F...
Mass spectrometry (MS)-based profiling of clinical specimens has been increasingly used in cancer research to characterize changes in protein expression between tumor and healthy tissue or be...
Advances in genomic research have led to identification of the majority of the drivers of tumor progression. However, our understanding of the molecular mechanisms propelling tumor growth is...
When the BCR/ABL1 fusion protein was identified in chronic myelogenous leukemia and the JAK2 V617F mutation was identified in patients with other myeloproliferative neoplasms (MPNs) such as p...
Human malignant glioma is a uniformly fatal disease, causing over 14,000 deaths in the US this year. Adults diagnosed with malignant brain tumors have a median survival of approximately 15 mo...
Understanding how genes coordinate their expression across cells in a growing embryo can provide insights into the transcriptional programs that control development. Intercellular variability...
The flexibility of the BioMark Real-Time PCR System, allow us to preform genetic research using different types of nano-fluidic (48.48 or 96.96) chips setup, in the thermal cycle of these chi...
The ENCODE and modENCODE consortia have generated a resource containing large amounts of transcriptomic data, extensive mapping of chromatin states, as well as the binding locations of >30...
The human genome encodes ~21,500 proteins that are subject to reversible phosphorylation at nearly 1 million phosphosites by about 538 protein kinases and 156 protein phosphatases. Amongst ot...
ATP-binding cassette transporter A1 (ABCA1) mediates cholesterol efflux to lipid-free apolipoproteins such as apolipoprotein A-I (apoA-I) and apolipoprotein E (apoE). ABCA1 is essential regul...
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