DNA Synthesis for mRNA Therapeutics: How to ensure good results by choosing the right DNA

Over the last two decades, DNA synthesis has established itself as a standard tool propelling life science research in a wide range of fields. In this session, we will highlight how DNA synthesis tools can support mRNA therapeutics development.

One key benefit of synthetic DNA is that it enables flexible sequence design independent of any naturally occurring template. Methods for optimization of expression in a target organism will be discussed, focusing on how to achieve best results in mammalian systems. The ability to design sequences also enables incorporation of additional layers of information into the DNA. To this end, a method for “molecular watermarking” will be described, which can enable tracking and tracing of a molecule throughout the application.

mRNA Therapeutics have a wide range of applications ranging from personalized approaches in cancer immunotherapy to global applications in the infectious disease landscape. Depending on the application, the needs for DNA input differ widely. These needs will be discussed using specific examples of how Thermo Fisher GeneArt DNA synthesis technologies can address a variety of needs across myriad applications in the life science industry.

In summary, this presentation will highlight how different Synthetic Biology technologies can support emerging needs in mRNA therapeutics development and commercialization.

Learning Objectives:

1. Discover Synthetic Biology technologies to support emerging mRNA therapeutics needs

2. Learn about the importance of DNA input for Infectious Disease applications

3. Understand the different methods for optimization of DNA expression in target organisms