A Single-Cell and Spatially-Resolved Atlas of the Human and Murine Oral Cavity

The oral cavity serves as the gateway to both the respiratory and digestive tracts and shares structural features with the skin. Despite its specialized niches—labial and buccal mucosae, salivary glands, periodontium, palate, and tongue—our understanding of cellular heterogeneity, communication, and spatial patterns within these regions remains limited.

 

In this webinar, Dr. Inês Sequeira (Queen Mary University of London) will discuss how multi-omic spatial technologies have been used to build the first Oral Cell Atlas, for both mouse and human tissues. Key findings include 1) Shared and unique cell subpopulations across oral niches and other epithelia, suggesting niche-specific immune residency and 2) A unique fibroblast subpopulation in the buccal mucosa that may explain its scarless healing compared to skin. This comprehensive atlas offers new insights into oral tissue heterogeneity and serves as a valuable resource for research and clinical applications.

 

Learning Objectives