The UC Enuity Cryo is a fully outfitted ultramicrotome for basic room temperature ultramicrotomy applications as well as advanced cryoultramicrotomy applications. It includes an antistatic device as well as a dual micromanipulator system to facilitate Tokuyasu and CEMOVIS applications. The system can also be upgraded for more advanced room temperature applications such as automated trimming and alignment, automated serial sectioning for VolumeEM or automated trimming guided by microCT data.